Exhaled Breath Condensate: A Novel Matrix for Biological Monitoring to Assess Occupational Exposure to Respirable Crystalline Silica.
Biological monitoring (BM) is a useful way of determining overall exposures to chemical substances; however, in the case of respirable crystalline silica (RCS), this has not been analytically feasible in conventional biological matrices. The aim of this study was to investigate the utility of exhale...
| Publicado en: | Annals of Work Exposures & Health Vol. 61; no. 7; pp. 902 - 907 |
|---|---|
| Autores principales: | , , , |
| Formato: | pictorial research tables/charts tracings Journal Article |
| Publicado: |
Oxford University Press / USA
Aug2017
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=124595680&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 124595680 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23987308 KJ1E jtl: Annals of Work Exposures & Health issn: 23987308 maglogo: N pubinfo: dt: Aug2017 vid: 61 iid: 7 pid: 622 pub: Oxford University Press / USA artinfo: ui: 124595680 124595680 124595680 10.1093/annweh/wxx047 124595680 ppf: 902 ppct: 5 formats: fmt: @attributes: type: P tig: atl: Exhaled Breath Condensate: A Novel Matrix for Biological Monitoring to Assess Occupational Exposure to Respirable Crystalline Silica. aug: au: Leese, Elizabeth Staff, James F. Carolan, Vikki A. Morton, Jackie affil: Health and Safety Executive, Harpur Hill, Buxton SK17 9JN UK sug: subj: Expiration Occupational Exposure Silicon Dioxide Analysis Dust Environmental Monitoring Human Microscopy, Electron Plasma Gases Mass Spectrometry England Control Group Descriptive Statistics Data Analysis Software Funding Source ab: Biological monitoring (BM) is a useful way of determining overall exposures to chemical substances; however, in the case of respirable crystalline silica (RCS), this has not been analytically feasible in conventional biological matrices. The aim of this study was to investigate the utility of exhaled breath condensate (EBC) as a potential biological matrix in which to determine exposure to RCS. A small pilot study was undertaken collecting EBC from six quarry workers and six occupationally unexposed persons; the samples were analysed using both single particle inductively coupled plasma mass spectrometry (spICP-MS) and transmission electron microscopy (TEM). The results showed that EBC obtained from the occupationally unexposed persons exhibited low background levels of dissolved silica whilst silica particles of various sizes were present in samples from quarry workers. This is the first study to report EBC as a potential biological matrix that allows differentiation of RCS concentrations between samples from workers and occupationally unexposed controls. The results shown here confirm the presence of RCS in EBC by both spICP-MS and TEM. However, there are difficult analytical challenges still to be overcome before this can be used as a BM method to determine workplace exposure, these are currently being investigated. pubtype: Academic Journal doctype: pictorial research tables/charts tracings Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|