Classification of suicide attempters in schizophrenia using sociocultural and clinical features: A machine learning approach.

Objective Suicide is a major concern for those afflicted by schizophrenia. Identifying patients at the highest risk for future suicide attempts remains a complex problem for psychiatric interventions. Machine learning models allow for the integration of many risk factors in order to build an algorit...

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Publicado en:General Hospital Psychiatry Vol. 47; pp. 20 - 29
Autores principales: Hettige, Nuwan C., Nguyen, Thai Binh, Yuan, Chen, Rajakulendran, Thanara, Baddour, Jermeen, Bhagwat, Nikhil, Bani-Fatemi, Ali, Voineskos, Aristotle N., Mallar Chakravarty, M., De Luca, Vincenzo
Formato: research Journal Article
Publicado: Elsevier B.V. Jul2017
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Jul2017
      vid: 47
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      pub: Elsevier B.V.
      place: New York, New York
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        10.1016/j.genhosppsych.2017.03.001
        124610659
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        atl: Classification of suicide attempters in schizophrenia using sociocultural and clinical features: A machine learning approach.
      aug:
        au:
          Hettige, Nuwan C.
          Nguyen, Thai Binh
          Yuan, Chen
          Rajakulendran, Thanara
          Baddour, Jermeen
          Bhagwat, Nikhil
          Bani-Fatemi, Ali
          Voineskos, Aristotle N.
          Mallar Chakravarty, M.
          De Luca, Vincenzo
        affil: Group for Suicide Studies, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario M5T 1R8, Canada
      sug:
        subj:
          Suicide, Attempted
          Suicidal Ideation
          Suicide
          Schizophrenia
          Early Intervention
          Logistic Regression
          Scales
          Probability
          Regression
      ab: Objective Suicide is a major concern for those afflicted by schizophrenia. Identifying patients at the highest risk for future suicide attempts remains a complex problem for psychiatric interventions. Machine learning models allow for the integration of many risk factors in order to build an algorithm that predicts which patients are likely to attempt suicide. Currently it is unclear how to integrate previously identified risk factors into a clinically relevant predictive tool to estimate the probability of a patient with schizophrenia for attempting suicide. Methods We conducted a cross-sectional assessment on a sample of 345 participants diagnosed with schizophrenia spectrum disorders. Suicide attempters and non-attempters were clearly identified using the Columbia Suicide Severity Rating Scale (C-SSRS) and the Beck Suicide Ideation Scale (BSS). We developed four classification algorithms using a regularized regression, random forest, elastic net and support vector machine models with sociocultural and clinical variables as features to train the models. Results All classification models performed similarly in identifying suicide attempters and non-attempters. Our regularized logistic regression model demonstrated an accuracy of 67% and an area under the curve (AUC) of 0.71, while the random forest model demonstrated 66% accuracy and an AUC of 0.67. Support vector classifier (SVC) model demonstrated an accuracy of 67% and an AUC of 0.70, and the elastic net model demonstrated and accuracy of 65% and an AUC of 0.71. Conclusion Machine learning algorithms offer a relatively successful method for incorporating many clinical features to predict individuals at risk for future suicide attempts. Increased performance of these models using clinically relevant variables offers the potential to facilitate early treatment and intervention to prevent future suicide attempts.
      pubtype: Academic Journal
      doctype:
        research
        Journal Article
      ougenre: Article
    language: English
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