Factor XIII Subunit A in the Skin: Applications in Diagnosis and Treatment.
The role of factor XIII subunit A (FXIII-A) is not restricted to hemostasis. FXIII-A is also present intracellularly in several human cells and serves as a diagnostic marker in a wide range of dermatological diseases from inflammatory conditions to malignancies. In this review, we provide a guide on...
| Publicado en: | BioMed Research International Vol. 2017; pp. 1 - 15 |
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| Autores principales: | , |
| Formato: | review tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
8/15/2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=124624861&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 124624861 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 8/15/2017 vid: 2017 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 124624861 124624861 124624861 10.1155/2017/3571861 124624861 ppf: 1 ppct: 14 formats: fmt: @attributes: type: P tig: atl: Factor XIII Subunit A in the Skin: Applications in Diagnosis and Treatment. aug: au: Paragh, Lilla Törőcsik, Daniel affil: Department of Dermatology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary sug: subj: Blood Coagulation Factors Fibrin Physiology Skin Anatomy and Histology Enzymes Hemostasis Cell Physiology Human Skin Diseases Diagnosis Inflammation Physiopathology Skin Neoplasms Dermis Wound Healing Dendritic Cells Macrophages Mast Cells Fibrin Therapeutic Use Gene Expression Angiogenic Proteins Dermatology ab: The role of factor XIII subunit A (FXIII-A) is not restricted to hemostasis. FXIII-A is also present intracellularly in several human cells and serves as a diagnostic marker in a wide range of dermatological diseases from inflammatory conditions to malignancies. In this review, we provide a guide on the still controversial interpretation of dermal cell types expressing FXIII-A and assess the previously described mechanisms behind their accumulation under physiological and pathological conditions of the human skin. We summarize the intracellular functions of FXIII-A as well as its possible sources in the extracellular space of the dermis with a focus on its relevance to skin homeostasis and disease pathogenesis. Finally, the potential role of FXIII-A in wound healing, as a field with long-term therapeutic implications, is also discussed. pubtype: Academic Journal doctype: review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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