Subthalamic nucleus stimulation effects on single and combined task performance in Parkinson's disease patients: a PET study.
Subthalamic nucleus deep brain stimulation (STN-DBS) represents one of the most efficacious treatments for Parkinson's disease, along with L-dopa therapy. The objective of the present work was to identify the cerebral networks associated with hand movement and speech production tasks performed alone...
| Publicado en: | Brain Imaging & Behavior Vol. 11; no. 4; pp. 1139 - 1154 |
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| Autores principales: | , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Aug2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=124638245&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 124638245 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Aug2017 vid: 11 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 124638245 124638245 144185070 NLM27704407 124638245 10.1007/s11682-016-9588-4 NLM27704407 124638245 ppf: 1139 ppct: 15 formats: fmt: @attributes: type: P tig: atl: Subthalamic nucleus stimulation effects on single and combined task performance in Parkinson's disease patients: a PET study. aug: au: Atkinson-Clement, Cyril Maillet, Audrey LeBars, Didier Lavenne, Franck Redouté, Jérôme Krainik, Alexandre Pollak, Pierre Thobois, Stéphane Pinto, Serge Redouté, Jérôme Thobois, Stéphane affil: Aix Marseille Univ, CNRS, LPL , Aix-en-Provence France sug: subj: Motor Activity Physiology Deep Brain Stimulation Speech Physiology Diencephalon Physiopathology Parkinson Disease Therapy Parkinson Disease Physiopathology Middle Age Human Hand Physiopathology Female Magnetic Resonance Imaging Male Reaction Time Parkinson Disease Tomography, Emission-Computed Aged Validation Studies Comparative Studies Evaluation Research Multicenter Studies Scales Middle Aged: 45-64 years Aged: 65+ years Female Male ab: Subthalamic nucleus deep brain stimulation (STN-DBS) represents one of the most efficacious treatments for Parkinson's disease, along with L-dopa therapy. The objective of the present work was to identify the cerebral networks associated with hand movement and speech production tasks performed alone and simultaneously, as well as the effects of STN-DBS on these profiles. Clinical, behavioral, and neuroimaging (oxygen 15-labeled water and Positron Emission Tomography) investigations were used to study single and combined performances of unilateral hand movements and speech production in 11 unmedicated individuals with PD, both off and on STN-DBS. Specifically, a flexible factorial design with the tasks (hand movement, speech production, combined task) and the STN-DBS conditions (off, on) as main factors was chosen for brain activation statistical analysis, using a Family-Wise Error corrected p-value at the cluster level of at least 10 contiguous voxels. Increased activation of fronto-parietal and cingulate areas was observed under STN-DBS for hand movement in single and combined tasks, respectively, reflecting a partial restoration of cortico-sub-cortical connections. The lack of results for speech production for both off and on STN-DBS could illustrate its relatively poor response to the treatment. STN-DBS tended to restore the additive function capacity that can be achieved when performing the combined task. We confirmed with original neuroimaging data that speech is much less responsive to STN-DBS than any other motor function and we concluded that speech outcomes following STN-DBS can be different from those observed pre-operatively following L-dopa administration. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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