Imbalanced functional link between reward circuits and the cognitive control system in patients with obsessive-compulsive disorder.
Altered reward processing and cognitive deficits are often observed in patients with obsessive-compulsive disorder (OCD); however, whether the imbalance in activity between reward circuits and the cognitive control (CC) system is associated with compulsive behavior remains unknown. Sixty-eight OCD p...
| Publicado en: | Brain Imaging & Behavior Vol. 11; no. 4; pp. 1099 - 1110 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Aug2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=124638248&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 124638248 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Aug2017 vid: 11 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 124638248 124638248 144097061 NLM27553440 124638248 10.1007/s11682-016-9585-7 NLM27553440 124638248 ppf: 1099 ppct: 11 formats: fmt: @attributes: type: P tig: atl: Imbalanced functional link between reward circuits and the cognitive control system in patients with obsessive-compulsive disorder. aug: au: Xie, Chunming Ma, Lisha Jiang, Nan Huang, Ruyan Li, Li Gong, Liang He, Cancan Xiao, Chaoyong Liu, Wen Xu, Shu Zhang, Zhijun affil: Department of Neurology, Affiliated ZhongDa Hospital, Neuropsychiatric Institute, Medical School , Southeast University , No. 87 DingJiaQiao Road Nanjing People's Republic of China 210009 sug: subj: Obsessive-Compulsive Disorder Physiopathology Brain Obsessive-Compulsive Disorder Brain Physiopathology Female Adult Male Neural Pathways Cross Sectional Studies Brain Mapping Magnetic Resonance Imaging Relaxation Reward Executive Function Human Psychological Tests Obsessive-Compulsive Disorder Psychosocial Factors Neural Pathways Physiopathology Validation Studies Comparative Studies Evaluation Research Multicenter Studies Clinical Assessment Tools Adult: 19-44 years Female Male ab: Altered reward processing and cognitive deficits are often observed in patients with obsessive-compulsive disorder (OCD); however, whether the imbalance in activity between reward circuits and the cognitive control (CC) system is associated with compulsive behavior remains unknown. Sixty-eight OCD patients and 33 cognitively normal (CN) healthy subjects participated in this resting-state functional magnetic resonance imaging study. Alterations in the functional connectivity between reward circuits and the CC system were quantitatively assessed and compared between the groups. A Granger causality analysis was used to determine the causal informational influence between and within reward circuits and the CC system across all subjects. OCD patients showed a dichotomous pattern of enhanced functional coupling in their reward circuits and a weakened functional coupling in their CC system when compared to CN subjects. Neural correlates of compulsive behavior were primarily located in the reward circuits and CC system in OCD patients. Importantly, the CC system exerted a reduced interregional causal influence over the reward system in OCD patients relative to its effect in CN subjects. The limitations of this study are that it was a cross-sectional study and the potential effects of environmental and genetic factors were not explored. OCD patients showed an imbalance in the functional link between reward circuits and the CC system at rest. This bias toward a loss of control may define a pathological state in which subjects are more vulnerable to engaging in compulsive behaviors. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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