Intrinsic network connectivity and own body perception in gender dysphoria.
Gender dysphoria (GD) is characterized by incongruence between one's identity and gender assigned at birth. The biological mechanisms of GD are unclear. We investigated brain network connectivity patterns involved in own body perception in the context of self in GD. Twenty-seven female-to-male (FtM)...
| Publicado en: | Brain Imaging & Behavior Vol. 11; no. 4; pp. 964 - 977 |
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| Autores principales: | , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Aug2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=124638252&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 124638252 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Aug2017 vid: 11 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 124638252 124638252 NLM27444730 124638252 10.1007/s11682-016-9578-6 NLM27444730 124638252 ppf: 964 ppct: 13 formats: fmt: @attributes: type: P tig: atl: Intrinsic network connectivity and own body perception in gender dysphoria. aug: au: Feusner, Jamie Lidström, Andreas Moody, Teena Dhejne, Cecilia Bookheimer, Susan Savic, Ivanka Feusner, Jamie D Lidström, Andreas Moody, Teena D Bookheimer, Susan Y affil: Department of Psychiatry and Biobehavioral Sciences , University of California Los Angeles , 300 UCLA Medical Plaza, suite 2200 Los Angeles 90095 USA sug: subj: Brain Physiopathology Body Image Transgender Persons Physiopathology Transgender Persons Neural Pathways Relaxation Adult Male Brain Mapping Magnetic Resonance Imaging Gender Identity Female Neural Pathways Physiopathology Human Brain Young Adult Adolescence Cross Sectional Studies Transgender Persons Psychosocial Factors Validation Studies Comparative Studies Evaluation Research Multicenter Studies Clinical Assessment Tools Short Portable Mental Status Questionnaire Adult: 19-44 years Adolescent: 13-18 years Male Female ab: Gender dysphoria (GD) is characterized by incongruence between one's identity and gender assigned at birth. The biological mechanisms of GD are unclear. We investigated brain network connectivity patterns involved in own body perception in the context of self in GD. Twenty-seven female-to-male (FtM) individuals with GD, 27 male controls, and 27 female controls underwent resting state fMRI. We compared functional connections within intrinsic connectivity networks involved in self-referential processes and own body perception -default mode network (DMN) and salience network - and visual networks, using independent components analyses. Behavioral correlates of network connectivity were also tested using self-perception ratings while viewing own body images morphed to their sex assigned at birth, and to the sex of their gender identity. FtM exhibited decreased connectivity of anterior and posterior cingulate and precuneus within the DMN compared with controls. In FtM, higher "self" ratings for bodies morphed towards the sex of their gender identity were associated with greater connectivity of the anterior cingulate within the DMN, during long viewing times. In controls, higher ratings for bodies morphed towards their gender assigned at birth were associated with right insula connectivity within the salience network, during short viewing times. Within visual networks FtM showed weaker connectivity in occipital and temporal regions. Results suggest disconnectivity within networks involved in own body perception in the context of self in GD. Moreover, perception of bodies in relation to self may be reflective rather than reflexive, as a function of mesial prefrontal processes. These may represent neurobiological correlates to the subjective disconnection between perception of body and self-identification. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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