Cortical thickness development of human primary visual cortex related to the age of blindness onset.
Blindness primarily induces structural alteration in the primary visual cortex (V1). Some studies have found that the early blind subjects had a thicker V1 compared to sighted controls, whereas late blind subjects showed no significant differences in the V1. This implies that the age of blindness on...
| Publicado en: | Brain Imaging & Behavior Vol. 11; no. 4; pp. 1029 - 1037 |
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| Autores principales: | , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Aug2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=124638254&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 124638254 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Aug2017 vid: 11 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 124638254 124638254 NLM27468855 124638254 10.1007/s11682-016-9576-8 NLM27468855 124638254 ppf: 1029 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Cortical thickness development of human primary visual cortex related to the age of blindness onset. aug: au: Li, Qiaojun Song, Ming Xu, Jiayuan Qin, Wen Yu, Chunshui Jiang, Tianzi affil: Department of Radiology , Tianjin Medical University General Hospital , Tianjin 300052 China sug: subj: Occipital Lobe Blindness Auditory Cortex Pathology Occipital Lobe Pathology Adult Dominance, Cerebral Parietal Lobe Blindness Physiopathology Blindness Epidemiology Frontal Lobe Auditory Cortex Image Processing, Computer Assisted Male Frontal Lobe Pathology Analysis of Variance Body Weights and Measures Parietal Lobe Pathology Blindness Pathology Age of Onset Human Magnetic Resonance Imaging Female Validation Studies Comparative Studies Evaluation Research Multicenter Studies Adult: 19-44 years Male Female ab: Blindness primarily induces structural alteration in the primary visual cortex (V1). Some studies have found that the early blind subjects had a thicker V1 compared to sighted controls, whereas late blind subjects showed no significant differences in the V1. This implies that the age of blindness onset may exert significant effects on the development of cortical thickness of the V1. However, no previous research used a trajectory of the age of blindness onset-related changes to investigate these effects. Here we explored this issue by mapping the cortical thickness trajectory of the V1 against the age of blindness onset using data from 99 blind individuals whose age of blindness onset ranged from birth to 34 years. We found that the cortical thickness of the V1 could be fitted well with a quadratic curve in both the left (F = 11.59, P = 3 × 10-5) and right hemispheres (F = 6.54, P = 2 × 10-3). Specifically, the cortical thickness of the V1 thinned rapidly during childhood and adolescence and did not change significantly thereafter. This trend was not observed in the primary auditory cortex (A1), primary motor cortex (M1), or primary somatosensory cortex (S1). These results provide evidence that an onset of blindness before adulthood significantly affects the cortical thickness of the V1 and suggest a critical period for cortical development of the human V1. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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