Disrupted functional connectome in antisocial personality disorder.
Studies on antisocial personality disorder (ASPD) subjects focus on brain functional alterations in relation to antisocial behaviors. Neuroimaging research has identified a number of focal brain regions with abnormal structures or functions in ASPD. However, little is known about the connections amo...
| Publicado en: | Brain Imaging & Behavior Vol. 11; no. 4; pp. 1071 - 1085 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Aug2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=124638258&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 124638258 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Aug2017 vid: 11 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 124638258 124638258 144062317 NLM27541949 124638258 10.1007/s11682-016-9572-z NLM27541949 124638258 ppf: 1071 ppct: 14 formats: fmt: @attributes: type: P tig: atl: Disrupted functional connectome in antisocial personality disorder. aug: au: Jiang, Weixiong Shi, Feng Liao, Jian Liu, Huasheng Wang, Tao Shen, Celina Shen, Hui Hu, Dewen Wang, Wei Shen, Dinggang affil: Department of Radiology and BRIC , University of North Carolina at Chapel Hill , 130 Mason Farm Road Chapel Hill 27599-7513 USA sug: subj: Brain Antisocial Personality Disorder Physiopathology Magnetic Resonance Imaging Brain Mapping Antisocial Personality Disorder Brain Physiopathology Neural Pathways Neural Pathways Physiopathology Human Relaxation Young Adult Male Public Offenders Validation Studies Comparative Studies Evaluation Research Multicenter Studies Clinical Assessment Tools Scales Male ab: Studies on antisocial personality disorder (ASPD) subjects focus on brain functional alterations in relation to antisocial behaviors. Neuroimaging research has identified a number of focal brain regions with abnormal structures or functions in ASPD. However, little is known about the connections among brain regions in terms of inter-regional whole-brain networks in ASPD patients, as well as possible alterations of brain functional topological organization. In this study, we employ resting-state functional magnetic resonance imaging (R-fMRI) to examine functional connectome of 32 ASPD patients and 35 normal controls by using a variety of network properties, including small-worldness, modularity, and connectivity. The small-world analysis reveals that ASPD patients have increased path length and decreased network efficiency, which implies a reduced ability of global integration of whole-brain functions. Modularity analysis suggests ASPD patients have decreased overall modularity, merged network modules, and reduced intra- and inter-module connectivities related to frontal regions. Also, network-based statistics show that an internal sub-network, composed of 16 nodes and 16 edges, is significantly affected in ASPD patients, where brain regions are mostly located in the fronto-parietal control network. These results suggest that ASPD is associated with both reduced brain integration and segregation in topological organization of functional brain networks, particularly in the fronto-parietal control network. These disruptions may contribute to disturbances in behavior and cognition in patients with ASPD. Our findings may provide insights into a deeper understanding of functional brain networks of ASPD. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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