In vitro skin expansion: Wound healing assessment.
ABSTRACT For treatments requiring split-thickness skin grafts, it is preferable to mesh the grafts. This reduces the amount of excised skin and covers more wound area. The mesh technique, however, destroys surface continuity, which results in scarring. Strain-based bioreactors, on the other hand, ha...
| Publicado en: | Wound Repair & Regeneration Vol. 25; no. 3; pp. 398 - 408 |
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| Autores principales: | , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
May/Jun2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=124751638&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 124751638 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10671927 DPV jtl: Wound Repair & Regeneration issn: 10671927 maglogo: Y pubinfo: dt: May/Jun2017 vid: 25 iid: 3 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 124751638 124751638 124751638 10.1111/wrr.12550 124751638 ppf: 398 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: In vitro skin expansion: Wound healing assessment. aug: au: Prim, Peter M. Kim, Han Su Shapiro, Lindsey E. Lee, Jae Sung Kaan, James H. Jackson, John D. Yoo, James J. Atala, Anthony Lee, Sang Jin affil: Wake Forest School of Medicine, Wake Forest Institute for Regenerative Medicine, Winston‐Salem North Carolina sug: subj: Wound Healing Evaluation Grafts Skin Transplantation In Vitro Studies Models, Biological Animal Studies Swine ab: ABSTRACT For treatments requiring split-thickness skin grafts, it is preferable to mesh the grafts. This reduces the amount of excised skin and covers more wound area. The mesh technique, however, destroys surface continuity, which results in scarring. Strain-based bioreactors, on the other hand, have successfully expanded split-thickness skin grafts in vitro within a 7-day period, increasing graft coverage. After in vitro expansion, the expanded skin grafts were tested in a porcine full-thickness excisional wound model. Expanded graft take rate was 100%. Volumetric, histologic, and mechanical assessments indicated that expanded grafts were comparable to unexpanded grafts (positive control). While there was considerable variation in expansion (31% to −3.1%), this technique has the potential to enhance the coverage area of skin grafts while reducing or eliminating scarring. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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