The potential of Ra and F-fluoride imaging to predict bone lesion response to treatment with Ra-dichloride in castration-resistant prostate cancer.
Purpose: The aims of this study were to calculate bone lesion absorbed doses resulting from a weight-based administration of Ra-dichloride, to assess the relationship between those doses and corresponding F-fluoride uptake and to assess the potential of quantitative F-fluoride imaging to predict res...
| Publicado en: | European Journal of Nuclear Medicine & Molecular Imaging Vol. 44; no. 11; pp. 1832 - 1845 |
|---|---|
| Autores principales: | , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Oct2017
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=124830903&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 124830903 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16197070 NPC jtl: European Journal of Nuclear Medicine & Molecular Imaging issn: 16197070 maglogo: N pubinfo: dt: Oct2017 vid: 44 iid: 11 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 124830903 144183813 10.1007/s00259-017-3744-y 124830903 ppf: 1832 ppct: 13 formats: fmt: @attributes: type: P tig: atl: The potential of Ra and F-fluoride imaging to predict bone lesion response to treatment with Ra-dichloride in castration-resistant prostate cancer. aug: au: Murray, Iain Chittenden, Sarah Denis-Bacelar, Ana Hindorf, Cecilia Parker, Christopher Chua, Sue Flux, Glenn affil: Department of Urology , Royal Marsden NHS Foundation Trust , Sutton UK sug: ab: Purpose: The aims of this study were to calculate bone lesion absorbed doses resulting from a weight-based administration of Ra-dichloride, to assess the relationship between those doses and corresponding F-fluoride uptake and to assess the potential of quantitative F-fluoride imaging to predict response to treatment. Methods: Five patients received two intravenous injections of Ra-dichloride, 6 weeks apart, at 110 kBq/kg whole-body weight. The biodistribution of Ra in metastatic lesions as a function of time after administration as well as associated lesion dosimetry were determined from serial Ra scans. PET/CT imaging using F-fluoride was performed prior to the first treatment (baseline), and at week 6 immediately before the second treatment and at week 12 after baseline. Results: Absorbed doses to metastatic bone lesions ranged from 0.6 Gy to 44.1 Gy. For individual patients, there was an average factor difference of 5.3 (range 2.5-11.0) between the maximum and minimum lesion dose. A relationship between lesion-absorbed doses and serial changes in F-fluoride uptake was demonstrated (r = 0.52). A log-linear relationship was demonstrated (r = 0.77) between baseline measurements of F-fluoride uptake prior to Ra-dichloride therapy and changes in uptake 12 weeks after the first cycle of therapy. Correlations were also observed between both Ra and F-fluoride uptake in lesions ( r = 0.75) as well as between Ra absorbed dose and F-fluoride uptake ( r = 0.96). Conclusions: There is both inter-patient and intra-patient heterogeneity of absorbed dose estimates to metastatic lesions. A relationship between Ra lesion absorbed dose and subsequent lesion response was observed. Analysis of this small group of patients suggests that baseline uptake of F-fluoride in bone metastases is significantly correlated with corresponding uptake of Ra, the associated Ra absorbed dose and subsequent lesion response to treatment. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|