Development of Diagnostic Techniques for Early Rheumatoid Arthritis Using Positron Emission Tomography with [11C]PK11195 and [11C]Ketoprofen Tracers.
Purpose: In vivo detection of pathological insults during the early stages of rheumatoid synovitis is essential to allow early anti-inflammatory treatment for prevention of joint destruction. Whether rheumatoid synovitis pathology and the efficacy of therapies can be visualized by positron emission...
| Publicado en: | Molecular Imaging & Biology Vol. 19; no. 5; pp. 746 - 754 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Oct2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=124865048&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 124865048 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15361632 KJU jtl: Molecular Imaging & Biology issn: 15361632 maglogo: N pubinfo: dt: Oct2017 vid: 19 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 124865048 124865048 144057449 NLM28050748 124865048 10.1007/s11307-016-1039-5 NLM28050748 124865048 ppf: 746 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Development of Diagnostic Techniques for Early Rheumatoid Arthritis Using Positron Emission Tomography with [11C]PK11195 and [11C]Ketoprofen Tracers. aug: au: Nozaki, Satoshi Ozaki, Naoko Suzuki, Shinobu Goto, Miki Mawatari, Aya Nakatani, Yuka Hayashinaka, Emi Wada, Yasuhiro Doi, Hisashi Watanabe, Yasuyoshi affil: RIKEN Center for Life Science Technologies , 6-7-3 Minatojima Minamimachi, Chuo-ku Kobe 650-0047 Japan sug: subj: Isoquinolines Tomography, Emission-Computed Radiopharmaceuticals Radioisotopes Arthritis, Rheumatoid Arthritis, Rheumatoid Diagnosis Acids, Carbocyclic Joints Pathology Models, Biological Animal Studies Inflammation Pathology Tomography, X-Ray Computed Imaging, Three-Dimensional Tumor Necrosis Factor Metabolism Tumor Necrosis Factor Antagonists and Inhibitors Arthritis, Rheumatoid Pathology Rats ab: Purpose: In vivo detection of pathological insults during the early stages of rheumatoid synovitis is essential to allow early anti-inflammatory treatment for prevention of joint destruction. Whether rheumatoid synovitis pathology and the efficacy of therapies can be visualized by positron emission tomography (PET) tracers specific to the inflammatory process was investigated.Procedures: Using a collagen-induced experimental rat model of rheumatoid arthritis, in vivo imaging using the PET tracers [11C]PK11195, which binds to the translocator protein mainly expressed on myeloid cells, and [11C]ketoprofen, for cyclooxygenase imaging, was performed. To evaluate therapeutic efficacy, model animals were administered the tumour necrosis factor alpha blocker etanercept subcutaneously.Results: [11C]PK11195 and [11C]ketoprofen uptakes were significantly higher in inflamed paws of collagen-induced arthritis rats than in normal rats. The data showed a correlation between tracer uptake values and paw swelling. After treatment with etanercept, [11C]ketoprofen uptake was significantly lower in treated animals than in untreated ones, whereas [11C]PK11195 uptake in the inflamed regions was comparable to that in the untreated group.Conclusions: With [11C]PK11195 and [11C]ketoprofen tracers, non-invasive in vivo PET imaging for rheumatoid synovitis can provide diagnostic evidence of early synovitis and allow monitoring inflammatory cell activity during treatment. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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