Chronic pistachio intake modulates circulating microRNAs related to glucose metabolism and insulin resistance in prediabetic subjects.
Purpose: To assess the effects of a pistachio-enriched diet on the profile of circulating microRNAs (miRNAs) related to glucose metabolism and insulin resistance (IR). Methods: Randomized crossover clinical trial in 49 subjects with prediabetes was performed. Subjects consumed a pistachio-supplement...
| Published in: | European Journal of Nutrition Vol. 56; no. 6; pp. 2181 - 2192 |
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| Main Authors: | , , , , |
| Format: | research tables/charts randomized controlled trial Journal Article |
| Published: |
Springer Nature
Sep2017
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=124912188&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 124912188 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Sep2017 vid: 56 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 124912188 124912188 124912188 10.1007/s00394-016-1262-5 124912188 ppf: 2181 ppct: 11 formats: fmt: @attributes: type: P tig: atl: Chronic pistachio intake modulates circulating microRNAs related to glucose metabolism and insulin resistance in prediabetic subjects. aug: au: Hernández-Alonso, Pablo Giardina, Simona Salas-Salvadó, Jordi Arcelin, Pierre Bulló, Mònica affil: Human Nutrition Unit, Biochemistry and Biotechnology Department, Faculty of Medicine and Health Sciences, University Hospital of Sant Joan de Reus, IISPV , Universitat Rovira i Virgili , St/Sant Llorenç 21 43201 Reus Spain sug: subj: Nuts Administration and Dosage RNA Physiology Blood Glucose Metabolism Insulin Resistance Prediabetic State Diet Therapy Human Randomized Controlled Trials Random Assignment Intervention Trials Crossover Design Reverse Transcriptase Polymerase Chain Reaction Statistical Significance P-Value Descriptive Statistics Insulin Blood ab: Purpose: To assess the effects of a pistachio-enriched diet on the profile of circulating microRNAs (miRNAs) related to glucose metabolism and insulin resistance (IR). Methods: Randomized crossover clinical trial in 49 subjects with prediabetes was performed. Subjects consumed a pistachio-supplemented diet (PD, 50 % carbohydrates, 33 % fat, including 57 g/day of pistachios) and an isocaloric control diet (CD, 55 % carbohydrates and 30 % fat) for 4 months each, separated by a 2-week washout period. The plasma profile of a set of seven predefined miRNAs related to glucose and insulin metabolism was analyzed by quantitative RT-PCR. Results: After the PD period, subjects have shown significant lower circulating levels of miR-192 and miR-375 compared to CD period, whereas miR-21 nonsignificantly increased after PD compared with CD (47 vs. 2 %, P = 0.092). Interestingly, changes in circulating miR-192 and miR-375 were positively correlated with plasma glucose, insulin and HOMA-IR. Conclusion: Chronic pistachio consumption positively modulates the expression of some miRNA previously implicated on insulin sensitivity. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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