Cardiovascular responses to sugary drinks in humans: galactose presents milder cardiac effects than glucose or fructose.
Purpose: There is increasing interest into the potentially beneficial effects of galactose for obesity and type 2 diabetes management as it is a low-glycemic sugar reported to increase satiety and fat mobilization. However, fructose is also a low-glycemic sugar but with greater blood pressure elevat...
| Publicado en: | European Journal of Nutrition Vol. 56; no. 6; pp. 2105 - 2114 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Springer Nature
Sep2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=124912195&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 124912195 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Sep2017 vid: 56 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 124912195 124912195 124912195 10.1007/s00394-016-1250-9 124912195 ppf: 2105 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Cardiovascular responses to sugary drinks in humans: galactose presents milder cardiac effects than glucose or fructose. aug: au: Charrière, Nathalie Loonam, Cathriona Montani, Jean-Pierre Dulloo, Abdul Grasser, Erik affil: Laboratory of Integrative Cardiovascular and Metabolic Physiology, Division of Physiology, Department of Medicine , University of Fribourg , 1700 Fribourg Switzerland sug: subj: Hexoses Administration and Dosage Hemodynamics Blood Pressure Human Randomized Controlled Trials Random Assignment Intervention Trials Crossover Design Male Glucose Administration and Dosage Fructose Administration and Dosage Beverages Blood Pressure Determination Electrocardiography Stroke Volume Evaluation Cardiac Output Determination Vascular Resistance Evaluation Statistical Significance P-Value Male ab: Purpose: There is increasing interest into the potentially beneficial effects of galactose for obesity and type 2 diabetes management as it is a low-glycemic sugar reported to increase satiety and fat mobilization. However, fructose is also a low-glycemic sugar but with greater blood pressure elevation effects than after glucose ingestion. Therefore, we investigated here the extent to which the ingestion of galactose, compared to glucose and fructose, impacts upon haemodynamics and blood pressure. Methods: In a randomized cross-over study design, 9 overnight-fasted young men attended 3 separate morning sessions during which continuous cardiovascular monitoring was performed at rest for at least 30 min before and 120 min after ingestion of 500 mL of water containing 60 g of either glucose, fructose or galactose. These measurements included beat-to-beat systolic and diastolic blood pressure, heart rate deduced by electrocardiography, and stroke volume derived by impedance cardiography; these measurements were used to calculate cardiac output and total peripheral resistance. Results: Ingestion of galactose, like glucose, led to significantly lesser increases in systolic, diastolic and mean blood pressure than fructose ingestion ( p < 0.05). Furthermore, the increase in cardiac output and reduction in total peripheral resistance observed after ingestion of glucose were markedly lower after galactose ingestion ( p < 0.01). Conclusions: Galactose thus presents the interesting characteristics of a low-glycemic sugar with mild cardiovascular effects. Further studies are warranted to confirm the clinical relevance of the milder cardiovascular effects of galactose than other sugars for insulin resistant obese and/or diabetic patients with cardiac insufficiency. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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