FLAIR* to visualize veins in white matter lesions: A new tool for the diagnosis of multiple sclerosis?
Objective: To explore the potential of a post-processing technique combining FLAIR and T2* (FLAIR*) to distinguish between lesions caused by multiple sclerosis (MS) from cerebral small vessel disease (SVD) in a clinical setting.Methods: FLAIR and T2* head datasets acquired at 3T of 25 people with re...
| Publicado en: | European Radiology Vol. 27; no. 10; pp. 4257 - 4264 |
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| Autores principales: | , , , , , , , , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Oct2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=124912446&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 124912446 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Oct2017 vid: 27 iid: 10 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 124912446 124912446 144177746 NLM28409356 10.1007/s00330-017-4822-z NLM28409356 124912446 ppf: 4257 ppct: 7 formats: fmt: @attributes: type: P tig: atl: FLAIR* to visualize veins in white matter lesions: A new tool for the diagnosis of multiple sclerosis? aug: au: Campion, T. Smith, R. Altmann, D. Brito, G. Turner, B. Evanson, J. George, I. Sati, P. Reich, D. Miquel, M. Schmierer, K. Smith, R J P Altmann, D R Brito, G C Turner, B P George, I C Reich, D S Miquel, M E affil: Department of Medical Statistics , London School of Hygiene and Tropical Medicine , London UK sug: subj: Veins Brain Magnetic Resonance Imaging Methods Neuroradiography Methods Multiple Sclerosis Pathology Male Brain Pathology Aged Cerebral Small Vessel Diseases Adult Sensitivity and Specificity Cerebral Ischemia Middle Age Female Interview Guides Scales Aged: 65+ years Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Objective: To explore the potential of a post-processing technique combining FLAIR and T2* (FLAIR*) to distinguish between lesions caused by multiple sclerosis (MS) from cerebral small vessel disease (SVD) in a clinical setting.Methods: FLAIR and T2* head datasets acquired at 3T of 25 people with relapsing MS (pwRMS) and ten with pwSVD were used. After post-processing, FLAIR* maps were used to determine the proportion of white matter lesions (WML) showing the 'vein in lesion' sign (VIL), a characteristic histopathological feature of MS plaques. Sensitivity and specificity of MS diagnosis were examined on the basis of >45% VIL+ and >60% VIL+ WML, and compared with current dissemination in space (DIS) MRI criteria.Results: All pwRMS had >45% VIL+ WML (range 58-100%) whilst in pwSVD the proportion of VIL+ WML was significantly lower (0-64%; mean 32±20%). Sensitivity based on >45% VIL+ was 100% and specificity 80% whilst with >60% VIL+ as the criterion, sensitivity was 96% and specificity 90%. DIS criteria had 96% sensitivity and 40% specificity.Conclusion: FLAIR* enables VIL+ WML detection in a clinical setting, facilitating differentiation of MS from SVD based on brain MRI.Key Points: • FLAIR* in a clinical setting allows visualization of veins in white matter lesions. • Significant proportions of MS lesions demonstrate a vein in lesion on MRI. • Microangiopathic lesions demonstrate a lower proportion of intralesional veins than MS lesions. • Intralesional vein-based criteria may complement current MRI criteria for MS diagnosis. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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