Accuracy of bone mineral density quantification using dual-layer spectral detector CT: a phantom study.
Objectives: To investigate the accuracy of bone mineral density (BMD) quantification using dual-layer spectral detector CT (SDCT) at various scan protocols.Methods: Two validated anthropomorphic phantoms containing inserts of 50-200 mg/cm3 calcium hydroxyapatite (HA) were scanned using a 64-slice SD...
| Publicado en: | European Radiology Vol. 27; no. 10; pp. 4351 - 4360 |
|---|---|
| Autores principales: | , , , , , , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Oct2017
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=124912461&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 124912461 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Oct2017 vid: 27 iid: 10 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 124912461 124912461 144086695 NLM28374079 10.1007/s00330-017-4801-4 NLM28374079 124912461 ppf: 4351 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Accuracy of bone mineral density quantification using dual-layer spectral detector CT: a phantom study. aug: au: Hamersvelt, Robbert Schilham, Arnold Engelke, Klaus Harder, Annemarie Keizer, Bart Verhaar, Harald Leiner, Tim Jong, Pim Willemink, Martin van Hamersvelt, Robbert W Schilham, Arnold M R den Harder, Annemarie M de Keizer, Bart Verhaar, Harald J de Jong, Pim A Willemink, Martin J affil: Department of Radiology , University Medical Centre Utrecht , 3508 GA Utrecht The Netherlands sug: subj: Tomography, X-Ray Computed Methods Bone Density Phantoms, Imaging Osteoporosis Absorptiometry, Photon Scales ab: Objectives: To investigate the accuracy of bone mineral density (BMD) quantification using dual-layer spectral detector CT (SDCT) at various scan protocols.Methods: Two validated anthropomorphic phantoms containing inserts of 50-200 mg/cm3 calcium hydroxyapatite (HA) were scanned using a 64-slice SDCT scanner at various acquisition protocols (120 and 140 kVp, and 50, 100 and 200 mAs). Regions of interest (ROIs) were placed in each insert and mean attenuation profiles at monochromatic energy levels (90-200 keV) were constructed. These profiles were fitted to attenuation profiles of pure HA and water to calculate HA concentrations. For comparison, one phantom was scanned using dual energy X-ray absorptiometry (DXA).Results: At both 120 and 140 kVp, excellent correlations (R = 0.97, P < 0.001) were found between true and measured HA concentrations. Mean error for all measurements at 120 kVp was -5.6 ± 5.7 mg/cm3 (-3.6 ± 3.2%) and at 140 kVp -2.4 ± 3.7 mg/cm3 (-0.8 ± 2.8%). Mean measurement errors were smaller than 6% for all acquisition protocols. Strong linear correlations (R2 ≥ 0.970, P < 0.001) with DXA were found.Conclusions: SDCT allows for accurate BMD quantification and potentially opens up the possibility for osteoporosis evaluation and opportunistic screening in patients undergoing SDCT for other clinical indications. However, patient studies are needed to extend and translate our findings.Key Points: • Dual-layer spectral detector CT allows for accurate bone mineral density quantification. • BMD measurements on SDCT are strongly linearly correlated to DXA. • SDCT, acquired for several indications, may allow for evaluation of osteoporosis. • This potentially opens up the possibility for opportunistic osteoporosis screening. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|