Genetic Predictors of ≥5% Weight Loss by Multidisciplinary Advice to Severely Obese Subjects.
Background: Weight loss success is determined by genetic factors, which may differ according to treatment strategy.Methods: From a multidisciplinary obesity treatment program involving dietary advice, psychological counseling, and increased physical activity, 587 subjects (68% female; 46.1 ± 12.4 ye...
| Publicado en: | Journal of Nutrigenetics & Nutrigenomics Vol. 10; no. 1/2; pp. 32 - 43 |
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| Autores principales: | , , , |
| Formato: | Journal Article |
| Publicado: |
Karger AG
Aug2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=124942239&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 124942239 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16616499 39R8 jtl: Journal of Nutrigenetics & Nutrigenomics issn: 16616499 maglogo: N pubinfo: dt: Aug2017 vid: 10 iid: 1/2 pid: 2485 pub: Karger AG artinfo: ui: 124942239 124942239 NLM28578327 10.1159/000469662 NLM28578327 124942239 ppf: 32 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Genetic Predictors of ≥5% Weight Loss by Multidisciplinary Advice to Severely Obese Subjects. aug: au: Aller, Erik E.J.G. Mariman, Edwin C.M. Bouwman, Freek G. van Baak, Marleen A. affil: Department of Human Biology and Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, The Netherlands sug: subj: Obesity, Morbid Pathology Weight Loss Obesity, Morbid Adipocytes Physiology Polymorphism, Genetic Models, Biological Life Style Adipocytes Pathology Proteins Female Peptide Hydrolases Obesity, Morbid Physiopathology Middle Age Genetics Time Factors Male Adult Genotype Weight Reduction Programs Disease Susceptibility Nutrigenomics Short Portable Mental Status Questionnaire Middle Aged: 45-64 years Adult: 19-44 years Female Male ab: Background: Weight loss success is determined by genetic factors, which may differ according to treatment strategy.Methods: From a multidisciplinary obesity treatment program involving dietary advice, psychological counseling, and increased physical activity, 587 subjects (68% female; 46.1 ± 12.4 years; BMI 39.9 ± 6.3) were recruited. At baseline, a blood sample was drawn for DNA isolation. Genotypes were determined for 30 polymorphisms in 25 candidate genes. The association between genotypes and weight loss was assessed after 3 months (short-term) and after 12 months of treatment (long-term). Weight loss was categorized as ≥5% or <5% of initial weight.Results: The G/G genotype of PLIN1 (rs2289487) and PLIN1 (rs2304795), the T/T genotype of PLIN1 (rs1052700), and the C/C genotype of MMP2 predicted ≥5% weight loss in the first 3 months. The C/G-G/G genotype of PPARγ (rs1801282) and the T/C genotype of TIMP4 (rs3755724) predicted ≥5% weight loss after 12 months. Subjects with the combination of PPARγ (rs1801282) C/G-G/G and TIMP4 (rs3755724) T/C lost even more weight.Conclusion: Polymorphisms in genes related to regulation of fat storage and structural adaptation of the adipocytes are predictors for weight loss success with different genes being relevant for short-term and long-term weight loss success. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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