High expression of long non-coding HOX antisense transcript RNA and its clinical significance in cancer tissues: A meta-analysis.
Background HOX antisense transcript RNA (HOTAIR) is a 2148 nt long, intergenic, non-coding RNA molecule, which is reported to be highly expressed in many types of cancers. This meta-analysis summarizes its expression in cancer. Methods We searched all eligible papers on the prognostic impact of HOTA...
| Publicado en: | Thoracic Cancer Vol. 8; no. 5; pp. 387 - 393 |
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| Autores principales: | , , , , , , , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Sep2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=124969917&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 124969917 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 17597706 BDCY jtl: Thoracic Cancer issn: 17597706 maglogo: Y pubinfo: dt: Sep2017 vid: 8 iid: 5 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 124969917 124969917 124969917 10.1111/1759-7714.12435 124969917 ppf: 387 ppct: 6 formats: tig: atl: High expression of long non-coding HOX antisense transcript RNA and its clinical significance in cancer tissues: A meta-analysis. aug: au: Wang, Lei Zhao, Yandong Qin, Yi Xuan, Yunpeng Qiu, Tong Fu, Bo Ren, Xiaoyang Jiao, Wenjie affil: General Thoracic Surgery, The Affiliated Hospital of Qingdao University, Qingdao China sug: subj: Gene Expression RNA Neoplasms Human Systematic Review Meta Analysis PubMed Odds Ratio Confidence Intervals Lymph Nodes Pathology Neoplasm Metastasis ab: Background HOX antisense transcript RNA (HOTAIR) is a 2148 nt long, intergenic, non-coding RNA molecule, which is reported to be highly expressed in many types of cancers. This meta-analysis summarizes its expression in cancer. Methods We searched all eligible papers on the prognostic impact of HOTAIR in cancer from inception to 30 September 2015 in Pub Med, CBMdisc, and the CNKI database. Only full texts were included. Revman 5.3 was used for meta-analysis. Results A total of 11 studies of 1010 cases were included in the meta-analysis. HOTAIR expression was higher in: cancer tissues in than adjacent or normal tissues (odds ratio [ OR] 37.52, 95% confidence interval [ CI] 18.94-74.31; P < 0.00001); in cancer tissues with lymph node metastasis than in those without lymph node metastasis ( OR 3.37, 95% CI 2.36-4.82; P < 0.00001); and in histological grades II-III than in histological grade I( OR 0.47, 95% CI 0.29-0.75; P = 0.002). Conclusion This study shows that HOTAIR may play an important role in cancer occurrence and development, but whether it is a marker of cancer diagnosis and reliable prognosis remains to be confirmed. More rigorous design and meticulous quality epidemiological studies are required. pubtype: Academic Journal doctype: meta analysis research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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