Urinary metabolites in patients undergoing coronary catheterization via the radial versus femoral artery approach.
The transradial approach (TRA) for coronary angiography and percutaneous coronary intervention is associated with lower rates of vascular complications and acute kidney injury when compared to the trans- femoral approach (TFA). Urine metabolites and proteins may be useful in identifying the dynamic...
| Published in: | Baylor University Medical Center Proceedings Vol. 30; no. 4; pp. 404 - 410 |
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| Main Authors: | , , , , , , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Taylor & Francis Ltd
2017
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=125112253&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 125112253 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 08998280 1XEP jtl: Baylor University Medical Center Proceedings issn: 08998280 maglogo: N pubinfo: dt: 2017 vid: 30 iid: 4 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 125112253 125112253 125112253 10.1080/08998280.2017.11930207 125112253 ppf: 404 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Urinary metabolites in patients undergoing coronary catheterization via the radial versus femoral artery approach. aug: au: Vasudevan, Anupama Schussler, Jeffrey M. McCullough, Peter A. Won, Jane I. Velasco, Carlos E. Ashcraft, Paula Bolanos, Ivy Williams, Matthew Bottiglieri, Teodoro affil: Baylor Heart and Vascular Institute, Dallas, Texas sug: subj: Heart Catheterization Methods Femoral Artery Proteins Metabolism Proteins Urine Radial Artery Human Descriptive Statistics P-Value Heat-Shock Proteins Alkanes Sulfuric Acids Coronary Angiography Endothelium Exploratory Research Pretest-Posttest Design Heart Catheterization Adverse Effects ab: The transradial approach (TRA) for coronary angiography and percutaneous coronary intervention is associated with lower rates of vascular complications and acute kidney injury when compared to the trans- femoral approach (TFA). Urine metabolites and proteins may be useful in identifying the dynamic changes at the vascular endothelial cell level. We attempted to explore the changes in the measurable signals of endothelial and nephron injury within 60 to 90 minutes after catheterization among those with the TRA and TFA approaches. Consecutive patients of a single interventionist who underwent coronary angiography between June 2015 and May 2016 were included. Of the 60 patients included in the analysis, the baseline characteristics were similar between those with a TRA (n = 30) and TFA (n = 30) approach. The values of the bio- markers were natural log transformed for the analysis. We found that the mean values of heat shock protein 27, taurine, and sulfuric acid did not significantly change after the procedure. However, the median value of thioredoxin decreased (P = 0.002) and that of talose increased (P = 0.01) after the procedure. None of the patients in our cohort experienced vascular complications or acute kidney injury. No differences in the values of urinary metabolites (pre, post, and delta) were found between TRA and TFA except for postprocedural thioredoxin. In conclusion, this exploratory study showed no difference in the patterns of acute vascular/renal injury metabolic markers before and after catheterization irrespective of the arterial access site. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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