Latent Class Analysis of Noninvasive Methods and Liver Biopsy in Chronic Hepatitis C: An Approach without a Gold Standard.
Aims. To evaluate the applicability of the Latent Class Analysis (LCA) and accuracy of transient elastography (TE), aspartate-to-platelet-ratio-index (APRI), enhanced liver fibrosis (ELF), and liver biopsy (LB) for liver fibrosis assessment in a model without a gold standard. Methods. Significant fi...
| Publicado en: | BioMed Research International Vol. 2017; pp. 1 - 9 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
9/13/2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=125132384&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 125132384 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 9/13/2017 vid: 2017 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 125132384 125132384 125132384 10.1155/2017/8252980 125132384 ppf: 1 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Latent Class Analysis of Noninvasive Methods and Liver Biopsy in Chronic Hepatitis C: An Approach without a Gold Standard. aug: au: Fernandes, Flavia F. Perazzo, Hugo Andrade, Luiz E. Dellavance, Alessandra Terra, Carlos Pereira, Gustavo Pereira, João L. Campos, Frederico Ferraz, Maria L. Perez, Renata M. affil: Gastroenterology and Hepatology Department, University of the State of Rio de Janeiro, Rio de Janeiro, RJ, Brazil sug: subj: Noninvasive Procedures Biopsy Hepatitis C, Chronic Diagnosis Human Hepatitis C, Chronic Physiopathology Data Analysis, Statistical Fibrosis Sensitivity and Specificity Biological Markers Male Female Body Mass Index Evaluation Middle Age Funding Source Middle Aged: 45-64 years Male Female ab: Aims. To evaluate the applicability of the Latent Class Analysis (LCA) and accuracy of transient elastography (TE), aspartate-to-platelet-ratio-index (APRI), enhanced liver fibrosis (ELF), and liver biopsy (LB) for liver fibrosis assessment in a model without a gold standard. Methods. Significant fibrosis was defined as TE≥7.1 kPa, APRI≥1.5, ELF≥9.37, or LB METAVIR F≥2. Cirrhosis was defined as TE≥12.5 kPa, APRI≥2.0, ELF≥10.31, or LB as METAVIR F=4. Results. 117 patients with chronic hepatitis C were included. In the LCA, for significant fibrosis the sensitivities and specificities (95% CI) were 0.92 (0.86–0.98) and 0.79 (0.72–0.86) for TE; 0.47 (0.40–0.54) and 0.99 (0.95–1.00) for APRI; 0.81 (0.74–0.88) and 0.78 (0.71–0.85) for ELF; and 0.86 (0.68–1.00) and 0.91 (0.79–1.00) for LB. For cirrhosis, the sensitivities and specificities were 0.92 (0.76–1.00) and 0.94 (0.91–0.97) for TE; 0.57 (0.37–0.77) and 0.97 (0.93–1.00) for APRI; 0.94 (0.84–1.00) and 0.88 (0.82–0.94) for ELF; and 0.30 (0.12–0.48) and 1.00 for LB. Conclusion. LCA was useful to evaluate accuracy of methods for liver fibrosis staging. Sensitivities and specificities of noninvasive methods were increased in LCA compared to the use of LB as the gold standard. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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