Normative values for CT-based texture analysis of vertebral bodies in dual X-ray absorptiometry-confirmed, normally mineralized subjects.
Objectives: To develop age-, gender-, and regional-specific normative values for texture analysis (TA) of spinal computed tomography (CT) in subjects with normal bone mineral density (BMD), as defined by dual X-ray absorptiometry (DXA), and to determine age-, gender-, and regional-specific differenc...
| Publicado en: | Skeletal Radiology Vol. 46; no. 11; pp. 1541 - 1552 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Nov2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=125148424&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 125148424 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03642348 O14 jtl: Skeletal Radiology issn: 03642348 maglogo: N pubinfo: dt: Nov2017 vid: 46 iid: 11 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 125148424 125148424 144195482 NLM28780746 125148424 10.1007/s00256-017-2728-0 NLM28780746 125148424 ppf: 1541 ppct: 11 formats: fmt: @attributes: type: P tig: atl: Normative values for CT-based texture analysis of vertebral bodies in dual X-ray absorptiometry-confirmed, normally mineralized subjects. aug: au: Mannil, Manoj Eberhard, Matthias Becker, Anton Schönenberg, Denise Osterhoff, Georg Frey, Diana Konukoglu, Ender Alkadhi, Hatem Guggenberger, Roman Becker, Anton S Schönenberg, Denise Frey, Diana P affil: Institute of Diagnostic and Interventional Radiology , University Hospital Zurich , Raemistrasse 100 8091 Zurich Switzerland sug: subj: Bone Density Physiology Lumbar Vertebrae Tomography, X-Ray Computed Methods Thoracic Vertebrae Lumbar Vertebrae Physiology Adult Absorptiometry, Photon Female Aged Middle Age Thoracic Vertebrae Physiology Reference Values Retrospective Design Male Human Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years Female Male ab: Objectives: To develop age-, gender-, and regional-specific normative values for texture analysis (TA) of spinal computed tomography (CT) in subjects with normal bone mineral density (BMD), as defined by dual X-ray absorptiometry (DXA), and to determine age-, gender-, and regional-specific differences.Materials and Methods: In this retrospective, IRB-approved study, TA was performed on sagittal CT bone images of the thoracic and lumbar spine using dedicated software (MaZda) in 141 individuals with normal DXA BMD findings. Numbers of female and male subjects were balanced in each of six age decades. Three hundred and five TA features were analyzed in thoracic and lumbar vertebrae using free-hand regions-of-interest. Intraclass correlation (ICC) coefficients were calculated for determining intra- and inter-observer agreement of each feature. Further dimension reduction was performed with correlation analyses.Results: The TA features with an ICC < 0.81 indicating compromised intra- and inter-observer agreement and with Pearson correlation scores r > 0.8 with other features were excluded from further analysis for dimension reduction. From the remaining 31 texture features, a significant correlation with age was found for the features mean (r = -0.489, p < 0.001), variance (r = -0.681, p < 0.001), kurtosis (r = 0.273, p < 0.001), and WavEnLL_s4 (r = 0.273, p < 0.001). Significant differences were found between genders for various higher-level texture features (p < 0.001). Regional differences among the thoracic spine, thoracic-lumbar junction, and lumbar spine were found for most TA features (p < 0.021).Conclusion: This study established normative values of TA features on CT images of the spine and showed age-, gender-, and regional-specific differences in individuals with normal BMD as defined by DXA. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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