Are Transplant Recipients Human Subjects When Research Is Conducted on Organ Donors?
Interventional research on deceased organ donors and donor organs prior to transplant holds the promise of reducing the number of patients who die waiting for an organ by expanding the pool of transplantable organs and improving transplant outcomes. However, one of the key challenges researchers fac...
| Publicado en: | Hastings Center Report Vol. 47; no. 5; pp. 10 - 15 |
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| Autores principales: | , |
| Formato: | Artículo |
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Wiley-Blackwell
Sep/Oct2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=125244895&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 125244895 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00930334 HCR jtl: Hastings Center Report issn: 00930334 maglogo: Y pubinfo: dt: Sep/Oct2017 vid: 47 iid: 5 pid: 480 pub: Wiley-Blackwell artinfo: ui: 125244895 10.1002/hast.757 ppf: 10 ppct: 5 formats: fmt: – @attributes: type: T – @attributes: type: P size: 241KB tig: atl: Are Transplant Recipients Human Subjects When Research Is Conducted on Organ Donors? aug: au: Heffernan, Kate Gallin Glazier, Alexandra K. su: Human research subjects Organ donors Transplantation of organs, tissues, etc. sug: subj: Human research subjects Organ donors Transplantation of organs, tissues, etc. ab: Interventional research on deceased organ donors and donor organs prior to transplant holds the promise of reducing the number of patients who die waiting for an organ by expanding the pool of transplantable organs and improving transplant outcomes. However, one of the key challenges researchers face is an assumption that someone who receives an organ that was part of an interventional research protocol is always a human subject of that same study. The consequences of this assumption include the need for oversight by an institutional review board and for research-level informed consent from transplant recipients, all within the complex practical realities of the organ donation and transplantation process in the United States. The current national focus on this issue provides an opportunity to think critically about the policy goals of the human subjects regulations and their application to the nascent field of deceased organ donor intervention research. We propose that for donor research where the transplant recipient does not fall under the definition of human subject, the clinical consent model-rather than the consent model used for human research subjects-best facilitates the policy objectives of balancing clinical innovation, transparency, and protection of patients in an ethically responsible and legally compliant manner. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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