Effect of a short-term dietary supplementation with phytosterols, red yeast rice or both on lipid pattern in moderately hypercholesterolemic subjects: a three-arm, double-blind, randomized clinical trial.
Background: Phytosterols and red yeast rice are largely studied cholesterol-lowering nutraceuticals, respectively inhibiting the bowel absorption and liver synthesis of cholesterol. Our aim was to test the effect on lipid profile of phytosterols, red yeast rice and their association. Methods: We per...
| Publicado en: | Nutrition & Metabolism Vol. 14; pp. 1 - 8 |
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| Autores principales: | , , , , , , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
BioMed Central
9/25/2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=125362055&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 125362055 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 17437075 1CYX jtl: Nutrition & Metabolism issn: 17437075 maglogo: N pubinfo: dt: 9/25/2017 vid: 14 pid: 24147 pub: BioMed Central artinfo: ui: 125362055 125362055 125362055 10.1186/s12986-017-0214-2 125362055 ppf: 1 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Effect of a short-term dietary supplementation with phytosterols, red yeast rice or both on lipid pattern in moderately hypercholesterolemic subjects: a three-arm, double-blind, randomized clinical trial. aug: au: Cicero, Arrigo F. G. Fogacci, Federica Rosticci, Martina Parini, Angelo Giovannini, Marina Veronesi, Maddalena D'Addato, Sergio Borghi, Claudio affil: Medical and Surgical Sciences Department, University of Bologna, Via Albertoni 15, 40138 Bologna, Italy sug: subj: Hypercholesterolemia Therapy Phytosterols Therapeutic Use Red Yeast Rice Fermentation Dietary Supplements Therapeutic Use Human Randomized Controlled Trials Random Assignment Double-Blind Studies Cholesterol Blood Statistical Significance P-Value Lipoproteins, LDL Cholesterol Blood Descriptive Statistics Apolipoproteins Blood Drug Combinations Therapeutic Use ab: Background: Phytosterols and red yeast rice are largely studied cholesterol-lowering nutraceuticals, respectively inhibiting the bowel absorption and liver synthesis of cholesterol. Our aim was to test the effect on lipid profile of phytosterols, red yeast rice and their association. Methods: We performed a three parallel arms, double blind, clinical trial randomizing 90 moderately hypercholesterolemic subjects to treatment with phytosterols 800 mg (group 1), red yeast rice standardized to contain 5 mg monacolins from Monascus purpureus (group 2), or both combined nutraceuticals (group 3). Results: After 8 weeks of treatment, in group 1 no significant variation of lipid parameters has been detected. In group 2 a significant reduction (p < 0.001) of LDL-Cholesterol (-20.5% vs. baseline) and Apolipoprotein B (-14.4% vs. baseline) as it occurred in group 3 (LDL-Cholesterol vs. baseline: -27.0%, Apolipoprotein B vs. baseline: -19.0%) (P < 0.001). LDL-Cholesterol and Apolipoprotein B changes were significantly different comparing group 2 with group 1 (P < 0.05), and group 3 with group 1 (P < 0.05). LDL-Cholesterol change was also significantly higher in group 3 than in group 2 (P < 0.05). Conclusion: The association of phytosterol and red yeast rice seems to have additive cholesterol lowering effect, reaching a clinically significant LDL-Cholesterol reduction in mildly hypercholesterolemic patients. Trial registration: ClinicalTrial.gov ID: NCT02603276, Registered 27/08/2015. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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