Alzheimer's Disease Diagnosis Relies on a Twofold Clinical-Biological Algorithm: Three Memory Clinic Case Reports.
The International Working Group recently provided revised criteria of Alzheimer's disease (AD) proposing that the diagnosis of typical amnesic AD should be established by a clinical-biological signature, defined by the phenotype of an "amnesic syndrome of the hippocampal type" (ASHT) combined with p...
| Publicado en: | Journal of Alzheimer's Disease Vol. 60; no. 2; pp. 577 - 584 |
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| Autores principales: | , , , , , , , , |
| Formato: | case study Journal Article |
| Publicado: |
Sage Publications Inc.
2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=125388559&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 125388559 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13872877 FLR jtl: Journal of Alzheimer's Disease issn: 13872877 maglogo: N pubinfo: dt: 2017 vid: 60 iid: 2 pid: 20732 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 125388559 125388559 NLM28869481 125388559 10.3233/JAD-170574 NLM28869481 125388559 ppf: 577 ppct: 7 formats: tig: atl: Alzheimer's Disease Diagnosis Relies on a Twofold Clinical-Biological Algorithm: Three Memory Clinic Case Reports. aug: au: Levy Nogueira, Marcel Samri, Dalila Epelbaum, Stéphane Lista, Simone Suppa, Per Spies, Lothar Hampel, Harald Dubois, Bruno Teichmann, Marc affil: Department of Neurology, Institute of Memory and Alzheimer's Disease, Pitié-Salpêtrière University Hospital, Paris, France sug: subj: Alzheimer's Disease Algorithms Peptides Tomography, Emission-Computed Male Aged Tomography, Emission-Computed, Single-Photon Fludeoxyglucose F 18 Metabolism Disease Progression Alzheimer's Disease Cerebrospinal Fluid Alkaloids Metabolism Nerve Tissue Proteins Female Aged: 65+ years Male Female ab: The International Working Group recently provided revised criteria of Alzheimer's disease (AD) proposing that the diagnosis of typical amnesic AD should be established by a clinical-biological signature, defined by the phenotype of an "amnesic syndrome of the hippocampal type" (ASHT) combined with positive in vivo evidence of AD pathophysiology in the cerebrospinal fluid (CSF) or on amyloid PET imaging. The application and clinical value of this refined diagnostic algorithm, initially intended for research purposes, is explored in three memory clinic cases presenting with different cognitive profiles including an ASHT, hippocampal atrophy, and CSF AD-biomarker data. The case reports highlight that the isolated occurrence of one of the two proposed AD criteria, ASHT or positive pathophysiological markers, does not provide a reliable diagnosis of typical AD. It is proposed that the twofold diagnostic IWG algorithm can be applied and operationalized in memory clinic settings to improve the diagnostic accuracy of typical amnesic AD in clinical practice. pubtype: Academic Journal doctype: case study Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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