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Multi-endpoint biological monitoring in combined, carcinogenic occupational exposures.

We aimed to develop a relevant multi-endpoint biomonitoring system by studying different genotoxicity biomarkers in complex carcinogenic exposures under occupational situations. Altogether 109 workers were followed in five different workplaces. The combined carcinogenic exposures were monitored in t...

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Published in:International Journal of Environmental Health Research Vol. 27; no. 5; pp. 323 - 332
Main Authors: Szendi, Katalin, Hornyák, László, Varga, Csaba
Format: research tables/charts Journal Article
Published: Taylor & Francis Ltd Oct2017
Online Access:View this record in EBSCOhost
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        09603123
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      jtl: International Journal of Environmental Health Research
      issn: 09603123
      maglogo: Y
    pubinfo:
      dt: Oct2017
      vid: 27
      iid: 5
      pid: 377
      pub: Taylor & Francis Ltd
      place: Philadelphia, Pennsylvania
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        10.1080/09603123.2017.1339783
        125434447
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      tig:
        atl: Multi-endpoint biological monitoring in combined, carcinogenic occupational exposures.
      aug:
        au:
          Szendi, Katalin
          Hornyák, László
          Varga, Csaba
        affil: Department of Environmental Health, Institute of Public Health Medicine, Medical School, University of Pécs, Pécs, Hungary
      sug:
        subj:
          Occupational Exposure
          Carcinogens, Environmental
          Environmental Monitoring
          Mutagenicity Tests
          Biological Markers Urine
          Multicenter Studies
          Human
          Work Environment
          Biological Markers Blood
          Cytogenetic Analysis
          Comparative Studies
          Mutation
          Chromosomes
          Biological Assay
      ab: We aimed to develop a relevant multi-endpoint biomonitoring system by studying different genotoxicity biomarkers in complex carcinogenic exposures under occupational situations. Altogether 109 workers were followed in five different workplaces. The combined carcinogenic exposures were monitored in the urine and peripheral blood samples using Ames mutagenicity test and cytogenetic analyzes. The different genotoxicity endpoints studied showed different results in the same carcinogenic exposure situations. The urinary mutagenicity tests provided more information and proved to be more sensitive compared to the cytogenetic tests in the majority of cases. In complex exposures multistep biomonitoring panel should be applied, because the exact mechanisms of the combination of single exposing agents are not known. Such a panel should involve monitoring different endpoints, e.g. point mutations, chromosomal mutations. A relatively affordable and rapid testing panel was developed using validated tests as Ames and cytogenetic assays, but its practical use should be confirmed by further investigations.
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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