Pathologists' Computer-Assisted Diagnosis...A Mock-up of a Prototype Information System to Facilitate Automation of Pathology Sign-out

Context.--Pathologists' computer-assisted diagnosis (pCAD) is a proposed framework for alleviating challenges through the automation of their routine sign-out work. Currently, hypothetical pCAD is based on a triad of advanced image analysis, deep integration with heterogeneous information systems, a...

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Published in:Archives of Pathology & Laboratory Medicine Vol. 141; no. 10; pp. 1413 - 1421
Main Authors: Farahani, Navid, Zheng Liu, Jutt, Dylan, Fine, Jeffrey L.
Format: diagnostic images pictorial Journal Article
Published: College of American Pathologists Oct2017
Online Access:View this record in EBSCOhost
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      dt: Oct2017
      vid: 141
      iid: 10
      pid: 2550
      pub: College of American Pathologists
      place: Northfield, Illinois
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        10.5858/arpa.2016-0214-OA
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        atl: Pathologists' Computer-Assisted Diagnosis...A Mock-up of a Prototype Information System to Facilitate Automation of Pathology Sign-out
      aug:
        au:
          Farahani, Navid
          Zheng Liu
          Jutt, Dylan
          Fine, Jeffrey L.
        affil: Computational Pathology, 3Scan, Inc., San Francisco, California
      sug:
        subj:
          Diagnosis, Computer Assisted
          Pathologists
          Systems Design
          Specimen Handling
          Breast Neoplasms Pathology
          Workflow
          Microscopy, Virtual
          Artificial Intelligence
          Automation
      ab: Context.--Pathologists' computer-assisted diagnosis (pCAD) is a proposed framework for alleviating challenges through the automation of their routine sign-out work. Currently, hypothetical pCAD is based on a triad of advanced image analysis, deep integration with heterogeneous information systems, and a concrete understanding of traditional pathology workflow. Prototyping is an established method for designing complex new computer systems such as pCAD. Objective.--To describe, in detail, a prototype of pCAD for the sign-out of a breast cancer specimen. Design.--Deidentified glass slides and data from breast cancer specimens were used. Slides were digitized into whole-slide images with an Aperio ScanScope XT, and screen captures were created by using vendor-provided software. The advanced workflow prototype was constructed by using PowerPoint software. Results.--We modeled an interactive, computer-assisted workflow: pCAD previews whole-slide images in the context of integrated, disparate data and predefined diagnostic tasks and subtasks. Relevant regions of interest (ROIs) would be automatically identified and triaged by the computer. A pathologist's sign-out work would consist of an interactive review of important ROIs, driven by required diagnostic tasks. The interactive session would generate a pathology report automatically. Conclusions.--Using animations and real ROIs, the pCAD prototype demonstrates the hypothetical sign-out in a stepwise fashion, illustrating various interactions and explaining how steps can be automated. The file is publicly available and should be widely compatible. This mock-up is intended to spur discussion and to help usher in the next era of digitization for pathologists by providing desperately needed and long-awaited automation.
      pubtype: Academic Journal
      doctype:
        diagnostic images
        pictorial
        Journal Article
      ougenre: Article
    language: English
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