The Incorporation of Strontium in a Sodium Alginate Coating on Titanium Surfaces for Improved Biological Properties.
Orthopedic implant failure is mainly attributed to the poor bonding of the implant to bone tissue. An effective approach to minimize the implant failure would be modifying the surface of the implant. Strontium (Sr) can stimulate the proliferation and differentiation of osteoblasts and reduce the act...
| Publicado en: | BioMed Research International Vol. 2017; pp. 1 - 12 |
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| Autores principales: | , , , , , , , , , |
| Formato: | equations & formulas pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
10/3/2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=125459304&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 125459304 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 10/3/2017 vid: 2017 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 125459304 125459304 125459304 10.1155/2017/9867819 125459304 ppf: 1 ppct: 11 formats: fmt: @attributes: type: P tig: atl: The Incorporation of Strontium in a Sodium Alginate Coating on Titanium Surfaces for Improved Biological Properties. aug: au: Jia, Lili Yuan, Ning Geng, Zhen Wang, Renfeng Li, Zhaoyang Yang, Xianjin Cui, Zhenduo Zhu, Shengli Liang, Yanqin Liu, Yunde affil: School of Materials Science & Engineering, Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin 300350, China sug: subj: Biological Products Analysis Elements Polysaccharides Titanium Chemistry Orthopedic Equipment and Supplies Prostheses and Implants Treatment Failure Osteoblasts Physiology Dopamine Therapeutic Use Microscopy, Electron Mass Spectrometry Cell Physiology Grafts Tissue and Organ Harvesting ab: Orthopedic implant failure is mainly attributed to the poor bonding of the implant to bone tissue. An effective approach to minimize the implant failure would be modifying the surface of the implant. Strontium (Sr) can stimulate the proliferation and differentiation of osteoblasts and reduce the activity of osteoclasts. In this study, a titanium (Ti) surface was successively functionalized by covalently grafting dopamine, sodium alginate (SA), and Sr2+ via the electrostatic immobilization method. The as-prepared coatings on the Ti surface were characterized by using scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FT-IR), and contact angle. The results indicated that the Sr-incorporated coatings were successfully prepared and that Sr distributed uniformly on the surface. A long-lasting and sustained Sr release had been observed in Sr2+ release studies. The Ti/DOPA/SA/Sr exhibited little cytotoxicity and a robust effect of Sr incorporation on the adhesion and spreading of MG63 cells. The proliferation and alkaline phosphatase (ALP) activity of MG63 cells were enhanced by immobilizing Sr2+ on the SA-grafted Ti. The Sr-containing coatings, which displayed excellent biocompatibility and osteogenic activity, may provide a promising solution for promoting the tissue integration of implants. pubtype: Academic Journal doctype: equations & formulas pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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