Prolongation of the QTc interval in HIV-infected individuals compared to the general population.
Objectives: Prolonged QT interval is associated with arrhythmias and sudden death. An increased prevalence of QT interval prolongation in human immunodeficiency virus-infected (HIV) subjects was previously described. The impact of different medications and HIV infection itself on the QT interval is...
| Published in: | Infection Vol. 45; no. 5; pp. 659 - 668 |
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| Main Authors: | , , , , , , , , , , , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Springer Nature
Oct2017
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=125541168&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 125541168 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03008126 NXO jtl: Infection issn: 03008126 maglogo: N pubinfo: dt: Oct2017 vid: 45 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 125541168 125541168 144106960 125541168 10.1007/s15010-017-1053-9 125541168 ppf: 659 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Prolongation of the QTc interval in HIV-infected individuals compared to the general population. aug: au: Reinsch, Nico Arendt, Marina Geisel, Marie Schulze, Christina Holzendorf, Volker Warnke, Anna Neumann, Till Brockmeyer, Norbert Schadendorf, Dirk Eisele, Lewin Erbel, Raimund Moebus, Susanne Jöckel, Karl-Heinz Esser, Stefan affil: Institute for Medical Informatics, Biometry and Epidemiology (IMIBE) , University Hospital Essen , Essen Germany sug: subj: Electrocardiography Methods Long QT Syndrome HIV-Positive Persons Arrhythmia Mortality Human Male Female Heart Rate Descriptive Statistics Comparative Studies Smoking Diabetes Mellitus Male Female ab: Objectives: Prolonged QT interval is associated with arrhythmias and sudden death. An increased prevalence of QT interval prolongation in human immunodeficiency virus-infected (HIV) subjects was previously described. The impact of different medications and HIV infection itself on the QT interval is rarely investigated in large HIV+ cohorts. Methods: We compared QT interval measurement in 496 HIV(+) patients of the HIV-HEART study (HIVH) and 992 sex- and age-matched controls of the population-based German Heinz Nixdorf Recall study (HNR). QT corrected for heart rate (QTc) >440 ms in male and >460 ms in female was considered pathological. We analysed the impact of HIV status and HIV medication on QTc prolongation in the HIVH subjects. Results: We observed longer QTc in HIVH subjects compared with HNR controls: 424.1 ms ± 23.3 vs. 411.3 ± 15.3 ms for male and 435.5 ms ± 19.6 vs. 416.4 ms ± 17.3 for female subjects ( p < 0.0001 for both sexes). Adjusting for QT prolonging medication the mean differences in QTc between the two studies remained significant with 12.6 ms (95% CI 10.5-14.8; p value <0.0001) for male and 19.3 ms (95% CI 14.5-24.2; p value <0.0001) for female subjects. Prolongation of QTc was pathologic in 22.8 vs. 3.9% of HIV(+) and non-infected males and in 12.1 vs. 1.8% of the females [OR of 7.9 (5.0-12.6) and OR of 6.7 (1.8-24.2), respectively]. Smoking behaviour was an independent factor to lengthen QTc in HIV(+) patients. Diabetes mellitus was not a risk factor itself, but might be associated with medication which was associated with LQT. We could not observe any influence of the HIV status, ART, or any co-medication on the QTc. Conclusions: Our study showed that HIV(+) patients had significantly longer QTc intervals compared to the general population. The number of patients with pathologic QTc prolongation was significantly increased in HIV(+) population. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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