Nucleus accumbens functional connectivity at age 20 is associated with trajectory of adolescent cannabis use and predicts psychosocial functioning in young adulthood.
Aims (1) To identify trajectories of cannabis use across adolescence, (2) to measure the influence of cannabis use characteristics on functional connectivity of the nucleus accumbens (NAcc) and (3) to assess whether patterns of functional connectivity related to cannabis use are associated with psyc...
| Publicado en: | Addiction Vol. 112; no. 11; pp. 1961 - 1971 |
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| Autores principales: | , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Nov2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=125541511&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 125541511 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09652140 AIO jtl: Addiction issn: 09652140 maglogo: Y pubinfo: dt: Nov2017 vid: 112 iid: 11 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 125541511 125541511 125541511 10.1111/add.13882 125541511 ppf: 1961 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Nucleus accumbens functional connectivity at age 20 is associated with trajectory of adolescent cannabis use and predicts psychosocial functioning in young adulthood. aug: au: Lichenstein, Sarah D. Musselman, Samuel Shaw, Daniel S. Sitnick, Stephanie Forbes, Erika E. affil: Department of Psychology, University of Pittsburgh, Pittsburgh PA, USA sug: subj: Basal Ganglia Physiology Brain Drug Effects Cannabis Substance Abuse Psychosocial Factors Human Female Male Adolescence Young Adult Brain Ultrasonography Magnetic Resonance Imaging P-Value Prospective Studies United States United States Affective Disorders Risk Factors Educational Status In Adulthood Adolescent: 13-18 years Female Male ab: Aims (1) To identify trajectories of cannabis use across adolescence, (2) to measure the influence of cannabis use characteristics on functional connectivity of the nucleus accumbens (NAcc) and (3) to assess whether patterns of functional connectivity related to cannabis use are associated with psychosocial functioning 2 years later. Design The Pitt Mother and Child Project (PMCP) is a prospective, longitudinal study of male youth at high risk for psychopathology based on family income and gender. Setting Participants were recruited between age 6 and 17 months from the Women, Infants and Children Nutritional Supplement program (WIC) in the Pittsburgh, Pennsylvania area. Participants A total of 158 PMCP young men contributed functional magnetic resonance imaging (fMRI) and substance use data at age 20 years. Measurements Latent class growth analysis was used to determine trajectories of cannabis use frequency from age 14 to 19 years. Psychophysiological interaction (PPI) analysis was used to measure functional connectivity between the NAcc and prefrontal cortex (PFC). Adolescent cannabis use trajectory, recent frequency of use and age of initiation were considered as developmental factors. We also tested whether functional connectivity was associated with depressive symptoms, anhedonia and educational attainment at age 22. Findings We identified three distinct trajectories of adolescent cannabis use, characterized by stable high, escalating or stable low use. The cannabis use trajectory group had a significant effect on NAcc functional connectivity to the medial PFC ( F = 11.32, Z = 4.04, Pfamily-wise error-corrected (FWE-corr) = 0.000). The escalating trajectory group displayed a pattern of negative NAcc-mPFC connectivity that was linked to higher levels of depressive symptoms ( r = -0.17, P < .05), anhedonia ( r = -0.19, P < .05) and lower educational attainment ( t = -2.77, P < .01) at age 22. Conclusions Pattern of cannabis use frequency across adolescence in US youth could have consequences for mood symptoms and educational attainment in early adulthood via altered function in neural reward circuitry. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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