A new methodological approach to adjust alcohol exposure distributions to improve the estimation of alcohol-attributable fractions.

Background and Aims To assess the burden of excessive alcohol use, researchers estimate alcohol-attributable fractions (AAFs) routinely. However, under-reporting in survey data can bias these estimates. We present an approach that adjusts for under-reporting in the estimation of AAFs, particularly w...

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Published in:Addiction Vol. 112; no. 11; pp. 2053 - 2064
Main Authors: Parish, William J., Aldridge, Arnie, Allaire, Benjamin, Ekwueme, Donatus U., Poehler, Diana, Guy, Gery P., Thomas, Cheryll C., Trogdon, Justin G.
Format: equations & formulas research tables/charts Journal Article
Published: Wiley-Blackwell Nov2017
Online Access:View this record in EBSCOhost
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      dt: Nov2017
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      pub: Wiley-Blackwell
      place: Malden, Massachusetts
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        10.1111/add.13880
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        atl: A new methodological approach to adjust alcohol exposure distributions to improve the estimation of alcohol-attributable fractions.
      aug:
        au:
          Parish, William J.
          Aldridge, Arnie
          Allaire, Benjamin
          Ekwueme, Donatus U.
          Poehler, Diana
          Guy, Gery P.
          Thomas, Cheryll C.
          Trogdon, Justin G.
        affil: RTI International, Research Triangle Park, NC, USA
      sug:
        subj:
          Alcohol Abuse
          Measurement Error
          Alcohol-Related Disorders
          Breast Neoplasms Risk Factors
          Models, Statistical
          Human
          Female
          Adolescence
          Adult
          Conceptual Framework
          Adolescent: 13-18 years
          Adult: 19-44 years
          Female
      ab: Background and Aims To assess the burden of excessive alcohol use, researchers estimate alcohol-attributable fractions (AAFs) routinely. However, under-reporting in survey data can bias these estimates. We present an approach that adjusts for under-reporting in the estimation of AAFs, particularly within subgroups. This framework is a refinement of a previous method conducted by Rehm et al. Methods We use a measurement error model to derive the 'true' alcohol distribution from a 'reported' alcohol distribution. The 'true' distribution leverages per-capita sales data to identify the distribution average and then identifies the shape of the distribution with self-reported survey data. Data are from the National Alcohol Survey (NAS), the National Household Survey on Drug Abuse (NHSDA) and the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). We compared our approach with previous approaches by estimating the AAF of female breast cancer cases. Results Compared with Rehm et al.'s approach, our refinement performs similarly under a gamma assumption. For example, among females aged 18-25 years, the two approaches produce estimates from NHSDA that are within a percentage point. However, relaxing the gamma assumption generally produces more conservative evidence. For example, among females aged 18-25 years, estimates from NHSDA based on the best-fitting distribution are only 19.33% of breast cancer cases, which is a much smaller proportion than the gamma-based estimates of approximately 28%. Conclusions A refinement of Rehm et al.'s approach to adjusting for underreporting in the estimation of alcohol-attributable fractions provides more flexibility. This flexibility can avoid biases associated with failing to account for the underlying differences in alcohol consumption patterns across different study populations. Comparisons of our refinement with Rehm et al.'s approach show that results are similar when a gamma distribution is assumed. However, results are appreciably lower when the best-fitting distribution is chosen versus gamma-based results.
      pubtype: Academic Journal
      doctype:
        equations & formulas
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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