Diffusion-weighted (DW) MRI in lung cancers: ADC test-retest repeatability.
Purpose: To determine the test-retest repeatability of Apparent Diffusion Coefficient (ADC) measurements across institutions and MRI vendors, plus investigate the effect of post-processing methodology on measurement precision.Methods: Thirty malignant lung lesions >2 cm in size (23 patients) were sc...
| Publicado en: | European Radiology Vol. 27; no. 11; pp. 4552 - 4563 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Nov2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=125580661&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 125580661 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Nov2017 vid: 27 iid: 11 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 125580661 125580661 NLM28396997 125580661 10.1007/s00330-017-4828-6 NLM28396997 125580661 ppf: 4552 ppct: 11 formats: fmt: @attributes: type: P tig: atl: Diffusion-weighted (DW) MRI in lung cancers: ADC test-retest repeatability. aug: au: Weller, Alex Papoutsaki, Marianthi Waterton, John Chiti, Arturo Stroobants, Sigrid Kuijer, Joost Blackledge, Matthew Morgan, Veronica deSouza, Nandita Papoutsaki, Marianthi Vasiliki Waterton, John C deSouza, Nandita M affil: CRUK Cancer Imaging Centre , Institute of Cancer Research and Royal Marsden NHS Foundation Trust , Downs Road Surrey SM2 5PT UK sug: subj: Neoplasm Staging Methods Lung Neoplasms Pathology Magnetic Resonance Imaging Methods Adult Female Diagnosis, Differential Prospective Studies Male Aged, 80 and Over Reproducibility of Results Body Weights and Measures Middle Age Aged Human ROC Curve Validation Studies Comparative Studies Evaluation Research Multicenter Studies Adult: 19-44 years Aged, 80 & over Middle Aged: 45-64 years Aged: 65+ years Female Male ab: Purpose: To determine the test-retest repeatability of Apparent Diffusion Coefficient (ADC) measurements across institutions and MRI vendors, plus investigate the effect of post-processing methodology on measurement precision.Methods: Thirty malignant lung lesions >2 cm in size (23 patients) were scanned on two occasions, using echo-planar-Diffusion-Weighted (DW)-MRI to derive whole-tumour ADC (b = 100, 500 and 800smm-2). Scanning was performed at 4 institutions (3 MRI vendors). Whole-tumour volumes-of-interest were copied from first visit onto second visit images and from one post-processing platform to an open-source platform, to assess ADC repeatability and cross-platform reproducibility.Results: Whole-tumour ADC values ranged from 0.66-1.94x10-3mm2s-1 (mean = 1.14). Within-patient coefficient-of-variation (wCV) was 7.1% (95% CI 5.7-9.6%), limits-of-agreement (LoA) -18.0 to 21.9%. Lesions >3 cm had improved repeatability: wCV 3.9% (95% CI 2.9-5.9%); and LoA -10.2 to 11.4%. Variability for lesions <3 cm was 2.46 times higher. ADC reproducibility across different post-processing platforms was excellent: Pearson's R2 = 0.99; CoV 2.8% (95% CI 2.3-3.4%); and LoA -7.4 to 8.0%.Conclusion: A free-breathing DW-MRI protocol for imaging malignant lung tumours achieved satisfactory within-patient repeatability and was robust to changes in post-processing software, justifying its use in multi-centre trials. For response evaluation in individual patients, a change in ADC >21.9% will reflect treatment-related change.Key Points: • In lung cancer, free-breathing DWI-MRI produces acceptable images with evaluable ADC measurement. • ADC repeatability coefficient-of-variation is 7.1% for lung tumours >2 cm. • ADC repeatability coefficient-of-variation is 3.9% for lung tumours >3 cm. • ADC measurement precision is unaffected by the post-processing software used. • In multicentre trials, 22% increase in ADC indicates positive treatment response. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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