Assessment of Tachykinin Receptor 3' Gene Polymorphism rs3733631 in Rosacea.
Background. Rosacea is a chronic skin disease, possibly following the neurogenic skin inflammation model. Neurokinin B, involved in the pathogenesis of Parkinson's disease, frequently coexisting with subsequent onset of rosacea, is an endogenous ligand of the tachykinin receptor 3 (TACR3). Methods....
| Published in: | International Scholarly Research Notices pp. 1 - 7 |
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| Main Authors: | , , , , , |
| Format: | research tables/charts Journal Article |
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Wiley-Blackwell
2015
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=125673808&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 125673808 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23567872 JWZI jtl: International Scholarly Research Notices issn: 23567872 maglogo: N pubinfo: dt: 2015 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 125673808 125673808 125673808 10.1155/2015/469402 125673808 ppf: 1 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Assessment of Tachykinin Receptor 3' Gene Polymorphism rs3733631 in Rosacea. aug: au: Karpouzis, Anthony Avgeridis, Paschalis Tripsianis, Gregory Gatzidou, Elisavet Kourmouli, Niki Veletza, Stavroula affil: Department of Dermatology, Faculty of Medicine, Democritus University ofThrace, 68100 Alexandroupolis, Greece sug: subj: Polymorphism, Genetic Acne Rosacea Parkinson Disease Chi Square Test Human Genotype Ligands Alleles Male Male ab: Background. Rosacea is a chronic skin disease, possibly following the neurogenic skin inflammation model. Neurokinin B, involved in the pathogenesis of Parkinson's disease, frequently coexisting with subsequent onset of rosacea, is an endogenous ligand of the tachykinin receptor 3 (TACR3). Methods. 128 rosacea patients and 121matched controls were genotyped for rs3733631 by PCR-RFLP and analyzed by chi-square test. Results. We observed statistically significant predominance of the C/G or G/G genotype (p = 0.006) and of the G allele (p = 0.004) in the papulopustular (PP) form of rosacea and statistically marginal significance of the C/G or G/G genotype in erythematotelangiectatic (ET) rosacea (p = 0.052). Significantly higher frequency of the C/G or G/G genotype and G allele in PP rosacea (p= 0.021 and p = 0.008, resp.) was ascertained within male patients. Conclusion. TACR3 rs3733631 G allele possibly predisposes the evolution of the initial phase of rosacea to the PP and not the ET form in male patients. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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