In Vivo Studies on the Influence of Bacteriophage Preparations on the Autoimmune Inflammatory Process.
Phage preparations used for phage therapy may have not only direct antibacterial action but also immunomodulating effects mediated by phages themselves as well as by bacterial antigens. Therefore phage application in patients with immune disorders, and especially with autoimmune diseases, requires s...
| Published in: | BioMed Research International Vol. 2017; pp. 1 - 10 |
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| Main Authors: | , , , , , , , , |
| Format: | pictorial research tables/charts Journal Article |
| Published: |
Wiley-Blackwell
10/22/2017
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=125802850&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 125802850 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 10/22/2017 vid: 2017 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 125802850 125802850 125802850 10.1155/2017/3612015 125802850 ppf: 1 ppct: 9 formats: fmt: @attributes: type: P tig: atl: In Vivo Studies on the Influence of Bacteriophage Preparations on the Autoimmune Inflammatory Process. aug: au: Międzybrodzki, Ryszard Borysowski, Jan Kłak, Marlena Jończyk-Matysiak, Ewa Obmińska-Mrukowicz, Bożena Suszko-Pawłowska, Agnieszka Bubak, Barbara Weber-Dąbrowska, Beata Górski, Andrzej affil: Bacteriophage Laboratory, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wroclaw, Poland sug: subj: Virus Diseases Diagnosis Autoimmune Diseases Inflammation Animal Studies Bacterial Infections Physiopathology Staphylococcal Infections Bacteriological Techniques Joint Diseases Therapy Arthritis Mice Male Female Data Analysis Software Mann-Whitney U Test Analysis of Variance Male Female ab: Phage preparations used for phage therapy may have not only direct antibacterial action but also immunomodulating effects mediated by phages themselves as well as by bacterial antigens. Therefore phage application in patients with immune disorders, and especially with autoimmune diseases, requires special attention. The aim of this study was to investigate the effect of phage lysates (staphylococcal phages A3/R, phi200, and MS-1 cocktail, enterococcal phage 15/P, Pseudomonas phage 119x, and E. coli T4 phage) as well as purified T4 phage on the course of murine collagen-induced arthritis (CIA), commonly used as an animal model of rheumatoid arthritis. Intraperitoneal application of phage lysates or purified T4 phage did not aggravate the course of autoimmune joint disease. Moreover, although endotoxins are known to potentiate CIA, the systemic administration of phage lysate of Pseudomonas aeruginosa, which contains debris of this Gram-negative bacillus, did not significantly influence CIA although the sonicate of the corresponding bacterial strain did. Interestingly, a purified T4 phage revealed some anti-inflammatory activity when applied under the therapeutic scheme. Our preliminary results do not suggest that phages may aggravate the symptoms of rheumatoid arthritis. In contrast T4 phage may even exert an immunosuppressive effect. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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