The interaction between 5-HTTLPR and stress exposure influences connectivity of the executive control and default mode brain networks.
We recently reported that the serotonin transporter polymorphism 5-HTTLPR moderates the relation between stress exposure and attention-deficit/hyperactivity disorder (ADHD) severity. This gene-environment interaction (GxE) has been previously tied to the processing of emotional stimuli, which is inc...
| Publicado en: | Brain Imaging & Behavior Vol. 11; no. 5; pp. 1486 - 1497 |
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| Autores principales: | , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Oct2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=125839876&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 125839876 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Oct2017 vid: 11 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 125839876 125839876 144123320 NLM27738993 125839876 10.1007/s11682-016-9633-3 NLM27738993 125839876 ppf: 1486 ppct: 11 formats: fmt: @attributes: type: P tig: atl: The interaction between 5-HTTLPR and stress exposure influences connectivity of the executive control and default mode brain networks. aug: au: Meer, Dennis Hartman, Catharina Pruim, Raimon Mennes, Maarten Heslenfeld, Dirk Oosterlaan, Jaap Faraone, Stephen Franke, Barbara Buitelaar, Jan Hoekstra, Pieter van der Meer, Dennis Hartman, Catharina A Pruim, Raimon H R Faraone, Stephen V Buitelaar, Jan K Hoekstra, Pieter J affil: Department of Psychiatry , University Medical Center Groningen, University of Groningen , 9700 RB Groningen The Netherlands sug: subj: Brain Physiopathology Membrane Proteins Attention Deficit Hyperactivity Disorder Physiopathology Phenotype Executive Function Stress, Psychological Physiopathology Brain Mapping Severity of Illness Indices Stress, Psychological Genetic Techniques Magnetic Resonance Imaging Attention Deficit Hyperactivity Disorder Adolescence Relaxation Attention Deficit Hyperactivity Disorder Psychosocial Factors Human Heterozygote Prospective Studies Cross Sectional Studies Brain Neural Pathways Physiopathology Neural Pathways Regression Validation Studies Comparative Studies Evaluation Research Multicenter Studies Adolescent: 13-18 years ab: We recently reported that the serotonin transporter polymorphism 5-HTTLPR moderates the relation between stress exposure and attention-deficit/hyperactivity disorder (ADHD) severity. This gene-environment interaction (GxE) has been previously tied to the processing of emotional stimuli, which is increasingly recognized to be a key factor in ADHD-related impairment. The executive control and default mode brain networks play an important role in the regulation of emotion processing, and altered connectivity of these networks has also been associated with ADHD. We therefore investigated whether resting-state connectivity of either of these networks mediates the relation of 5-HTTLPR and stress exposure with ADHD severity. Resting-state functional magnetic resonance imaging, genetic, and stress exposure questionnaire data was available for 425 adolescents and young adults (average age 17.2 years). We found that 5-HTTLPR S-allele carriers showed a more negative relation between stress exposure and connectivity of the executive control network than L-allele homozygotes, specifically in the pre/postcentral gyrus, striatum, and frontal pole. In the default mode network, we found a positive association between the GxE and supramarginal gyrus connectivity. Connectivity of either network did not significantly mediate the effect of this GxE on ADHD. Opposite effects of stress exposure on connectivity in the executive and default mode networks may contribute to findings that stress exposure is associated with lowered cognitive control and heightened levels of rumination and worrying, for S-allele carriers but not L-allele homozygotes. When combined, these effects on connectivity of both networks may relate to the emotional problems seen in individuals with ADHD. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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