Resting-state subcortical functional connectivity in HIV-infected patients on long-term cART.
Despite long-term successful treatment with cART, impairments in cognitive functioning are still being reported in HIV-infected patients. Since changes in cognitive function may be preceded by subtle changes in brain function, neuroimaging techniques, such as resting-state functional magnetic resona...
| Publicado en: | Brain Imaging & Behavior Vol. 11; no. 5; pp. 1555 - 1561 |
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| Autores principales: | , , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Oct2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=125839877&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 125839877 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Oct2017 vid: 11 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 125839877 125839877 144195204 NLM27744494 125839877 10.1007/s11682-016-9632-4 NLM27744494 125839877 ppf: 1555 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Resting-state subcortical functional connectivity in HIV-infected patients on long-term cART. aug: au: Janssen, Marloes Hinne, Max Janssen, Ronald Gerven, Marcel Steens, Stefan Góraj, Bozena Koopmans, Peter Kessels, Roy Janssen, Marloes A M Janssen, Ronald J van Gerven, Marcel A Steens, Stefan C Góraj, Bozena Koopmans, Peter P Kessels, Roy P C affil: Donders Institute for Brain, Cognition and Behaviour , Radboud University , Nijmegen the Netherlands sug: subj: Brain Drug Effects HIV Infections Drug Therapy HIV Infections Physiopathology Anti-HIV Agents Therapeutic Use Brain Physiopathology Brain Male Middle Age HIV Infections Prospective Studies Neural Pathways Physiopathology Adult Aged Relaxation Brain Mapping Methods Probability Algorithms Magnetic Resonance Imaging Neural Pathways Drug Therapy, Combination Female Human Middle Aged: 45-64 years Adult: 19-44 years Aged: 65+ years Male Female ab: Despite long-term successful treatment with cART, impairments in cognitive functioning are still being reported in HIV-infected patients. Since changes in cognitive function may be preceded by subtle changes in brain function, neuroimaging techniques, such as resting-state functional magnetic resonance imaging (rs-fMRI) have become useful tools in assessing HIV-associated abnormalities in the brain. The purpose of the current study was to examine the extent to which HIV infection in virologically suppressed patients is associated with disruptions in subcortical regions of the brain in comparison to a matched HIV-negative control group. The sample consisted of 72 patients and 39 controls included between January 2012 and January 2014. Resting state functional connectivity was determined between fourteen regions-of-interest (ROI): the left and right nucleus accumbens, amygdala, caudate nucleus, hippocampus, putamen, pallidum and thalamus. A Bayesian method was used to estimate resting-state functional connectivity, quantified in terms of partial correlations. Both groups showed the strongest partial correlations between the left and right caudate nucleus and the left and right thalamus. However, no differences between the HIV patients and controls were found between the posterior expected network densities (control network density = 0.26, SD = 0.05, patient network density = 0.26, SD = 0.04, p = 0.58). The results of the current study show that HIV does not affect subcortical connectivity in virologically controlled patients who are otherwise healthy. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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