Functional MRI signal fluctuations highlight altered resting brain activity in Huntington's disease.
The fractional Amplitude of Low Frequency Fluctuations (fALFF) and the degree of local synchronization (Regional Homogeneity - ReHo) of resting-state BOLD signal have been suggested to map spontaneous neuronal activity and local functional connectivity, respectively. We compared voxelwise, independe...
| Publicado en: | Brain Imaging & Behavior Vol. 11; no. 5; pp. 1459 - 1470 |
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| Autores principales: | , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Oct2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=125839878&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 125839878 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Oct2017 vid: 11 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 125839878 125839878 144020369 NLM27734308 10.1007/s11682-016-9630-6 NLM27734308 125839878 ppf: 1459 ppct: 11 formats: fmt: @attributes: type: P tig: atl: Functional MRI signal fluctuations highlight altered resting brain activity in Huntington's disease. aug: au: Sarappa, Chiara Salvatore, Elena Filla, Alessandro Cocozza, Sirio Russo, Cinzia Saccà, Francesco Brunetti, Arturo De Michele, Giuseppe Quarantelli, Mario Russo, Cinzia Valeria Saccà, Francesco affil: Department of Advanced Biomedical Sciences , University 'Federico II' , Edificio 10, Via S. Pansini 5 80131 Naples Italy sug: subj: Magnetic Resonance Imaging Brain Brain Physiopathology Huntington's Disease Physiopathology Huntington's Disease Oxygen Blood Male Adult Young Adult Dominance, Cerebral Heterozygote Adolescence Female Severity of Illness Indices Aged Brain Mapping Cerebrovascular Circulation Physiology Relaxation Middle Age Early Diagnosis Clinical Assessment Tools Adult: 19-44 years Adolescent: 13-18 years Aged: 65+ years Middle Aged: 45-64 years Male Female ab: The fractional Amplitude of Low Frequency Fluctuations (fALFF) and the degree of local synchronization (Regional Homogeneity - ReHo) of resting-state BOLD signal have been suggested to map spontaneous neuronal activity and local functional connectivity, respectively. We compared voxelwise, independent of atrophy, the fALFF and ReHo patterns of 11 presymptomatic (ps-HD) and 28 symptomatic (sHD) Huntington's disease mutation carriers, with those of 40 normal volunteers, and tested their possible correlations with the motor and cognitive subscores of the Unified Huntington's Disease Rating Scale. In sHD patients, fALFF was mainly reduced bilaterally in parietal lobes (right precuneus being already affected in psHD), and in superior frontal gyri, and increased bilaterally in cerebellar lobules VI, VIII and IX, as well as in the right inferior temporal gyrus. In sHD, and to a lesser extent in psHD, ReHo was bilaterally reduced in putamina, cerebellar lobules III to VI, and superior medial frontal gyri, and increased in both psHD and sHD in fronto-basal cortices, and in the right temporal lobe. fALFF correlated inversely with cognitive scores in lobule IX of the cerebellum (mainly with total Stroop score, p < 0.0001), and in the medial portions of both thalami. These results are consistent with a reduced neuronal activity in the cortical components of the executive networks, known to be affected in Huntington's Disease, and with reduced local functional integration in subcortical and cerebellar components of the sensori-motor network. Cerebellar clusters of significant correlation of fALFF with executive function scores may be related to compensatory mechanisms. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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