Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex.
The two hemispheres of the human brain differ functionally and structurally. Despite over a century of research, the extent to which brain asymmetry is influenced by sex, handedness, age, and genetic factors is still controversial. Here we present the largest ever analysis of subcortical brain asymm...
| Publicado en: | Brain Imaging & Behavior Vol. 11; no. 5; pp. 1497 - 1515 |
|---|---|
| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Oct2017
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=125839879&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 125839879 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Oct2017 vid: 11 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 125839879 125839879 144136655 NLM27738994 125839879 10.1007/s11682-016-9629-z NLM27738994 125839879 ppf: 1497 ppct: 18 formats: fmt: @attributes: type: P tig: atl: Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex. aug: au: Guadalupe, Tulio Mathias, Samuel vanErp, Theo Whelan, Christopher Zwiers, Marcel Abe, Yoshinari Abramovic, Lucija Agartz, Ingrid Andreassen, Ole Arias-Vásquez, Alejandro Aribisala, Benjamin Armstrong, Nicola Arolt, Volker Artiges, Eric Ayesa-Arriola, Rosa Baboyan, Vatche Banaschewski, Tobias Barker, Gareth Bastin, Mark Baune, Bernhard affil: Department of Psychiatry , Yale School of Medicine , New Haven 06519 USA sug: subj: Aging Dominance, Cerebral Reproduction Brain Magnetic Resonance Imaging Human Meta Analysis Funding Source ab: The two hemispheres of the human brain differ functionally and structurally. Despite over a century of research, the extent to which brain asymmetry is influenced by sex, handedness, age, and genetic factors is still controversial. Here we present the largest ever analysis of subcortical brain asymmetries, in a harmonized multi-site study using meta-analysis methods. Volumetric asymmetry of seven subcortical structures was assessed in 15,847 MRI scans from 52 datasets worldwide. There were sex differences in the asymmetry of the globus pallidus and putamen. Heritability estimates, derived from 1170 subjects belonging to 71 extended pedigrees, revealed that additive genetic factors influenced the asymmetry of these two structures and that of the hippocampus and thalamus. Handedness had no detectable effect on subcortical asymmetries, even in this unprecedented sample size, but the asymmetry of the putamen varied with age. Genetic drivers of asymmetry in the hippocampus, thalamus and basal ganglia may affect variability in human cognition, including susceptibility to psychiatric disorders. pubtype: Academic Journal doctype: meta analysis pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|