Functional connectivity abnormalities and associated cognitive deficits in fetal alcohol Spectrum disorders (FASD).
Consistent with well-documented structural and microstructural abnormalities in prenatal alcohol exposure (PAE), recent studies suggest that functional connectivity (FC) may also be disrupted. We evaluated whole-brain FC in a large multi-site sample, examined its cognitive correlates, and explored i...
| Published in: | Brain Imaging & Behavior Vol. 11; no. 5; pp. 1432 - 1446 |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , |
| Format: | research Journal Article |
| Published: |
Springer Nature
Oct2017
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=125839883&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 125839883 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Oct2017 vid: 11 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 125839883 125839883 144024227 NLM27734306 125839883 10.1007/s11682-016-9624-4 NLM27734306 125839883 ppf: 1432 ppct: 14 formats: fmt: @attributes: type: P tig: atl: Functional connectivity abnormalities and associated cognitive deficits in fetal alcohol Spectrum disorders (FASD). aug: au: Wozniak, Jeffrey Mueller, Bryon Mattson, Sarah Coles, Claire Kable, Julie Jones, Kenneth Boys, Christopher Lim, Kelvin Riley, Edward Sowell, Elizabeth Wozniak, Jeffrey R Mueller, Bryon A Mattson, Sarah N Coles, Claire D Kable, Julie A Jones, Kenneth L Boys, Christopher J Lim, Kelvin O Riley, Edward P Sowell, Elizabeth R affil: Department of Psychiatry , University of Minnesota Twin Cities , F282/2A West, 2450 Riverside Ave Minneapolis 55454 USA sug: subj: Brain Physiopathology Fetal Alcohol Syndrome Physiopathology Adolescence Retrospective Design Fetal Alcohol Syndrome Psychosocial Factors Multivariate Analysis Male Human Relaxation Brain Mapping Neuropsychological Tests Fetal Alcohol Syndrome Magnetic Resonance Imaging Neural Pathways Physiopathology Child Female Neural Pathways Brain Validation Studies Comparative Studies Evaluation Research Multicenter Studies Funding Source Adolescent: 13-18 years Child: 6-12 years Male Female ab: Consistent with well-documented structural and microstructural abnormalities in prenatal alcohol exposure (PAE), recent studies suggest that functional connectivity (FC) may also be disrupted. We evaluated whole-brain FC in a large multi-site sample, examined its cognitive correlates, and explored its potential to objectively identify neurodevelopmental abnormality in individuals without definitive dysmorphic features. Included were 75 children with PAE and 68 controls from four sites. All participants had documented heavy prenatal alcohol exposure. All underwent a formal evaluation of physical anomalies and dysmorphic facial features. MRI data were collected using modified matched protocols on three platforms (Siemens, GE, and Philips). Resting-state FC was examined using whole-brain graph theory metrics to characterize each individual's connectivity. Although whole-brain FC metrics did not discriminate prenatally-exposed from unexposed overall, atypical FC (> 1 standard deviation from the grand mean) was significantly more common (2.7 times) in the PAE group vs.Controls: In a subset of 55 individuals (PAE and controls) whose dysmorphology examination could not definitively characterize them as either Fetal Alcohol Syndrome (FAS) or non-FAS, atypical FC was seen in 27 % of the PAE group, but 0 % of controls. Across participants, a 1 % difference in local network efficiency was associated with a 36 point difference in global cognitive functioning. Whole-brain FC metrics have potential to identify individuals with objective neurodevelopmental abnormalities from prenatal alcohol exposure. When applied to individuals unable to be classified as FAS or non-FAS from dysmorphology alone, these measures separate prenatally-exposed from non-exposed with high specificity. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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