Task-Related Functional Connectivity Analysis of Emotion Discrimination in a Family Study of Schizophrenia.
Poor emotion recognition is a core deficit in schizophrenia and is associated with poor functional outcome. Functional magnetic resonance imaging (fMRI) multivariate analysis methods were used to elucidate the neural underpinnings of face and emotion processing associated with both genetic liability...
| Published in: | Schizophrenia Bulletin Vol. 43; no. 6; pp. 1348 - 1363 |
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| Main Authors: | , , , |
| Format: | pictorial research tables/charts Journal Article |
| Published: |
Oxford University Press / USA
Nov2017
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=125851433&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 125851433 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 05867614 2CZ jtl: Schizophrenia Bulletin issn: 05867614 maglogo: N pubinfo: dt: Nov2017 vid: 43 iid: 6 pid: 622 pub: Oxford University Press / USA artinfo: ui: 125851433 125851433 125851433 10.1093/schbul/sbx004 125851433 ppf: 1348 ppct: 15 formats: tig: atl: Task-Related Functional Connectivity Analysis of Emotion Discrimination in a Family Study of Schizophrenia. aug: au: Goghari, Vina M. Sanford, Nicole Spilka, Michael J. Woodward, Todd S. affil: Department of Psychology, University of Toronto, Toronto, ON, Canada sug: subj: Emotions Evaluation Schizophrenia Familial and Genetic Discrimination Human Magnetic Resonance Imaging Methods Multivariate Analysis Extended Family Visual Perception Facial Expression Ageism Amygdala Comparative Studies Control Group Fear Anger Reaction Time ab: Poor emotion recognition is a core deficit in schizophrenia and is associated with poor functional outcome. Functional magnetic resonance imaging (fMRI) multivariate analysis methods were used to elucidate the neural underpinnings of face and emotion processing associated with both genetic liability and disease-specific effects. Schizophrenia patients, relatives, and controls completed a task that included 4 facial emotion discrimination conditions and an age discrimination condition during fMRI. Three functional networks were derived from the data: the first involved in visual attention and response generation, the second a default mode network (DMN), and a third involved in face and emotion processing. No differences in activation were found between groups for the visual attention and response generation network, suggesting that basic processes were intact. Both schizophrenia patients and relatives showed evidence for hyperdeactivation in the DMN compared to controls, with relatives being intermediate, suggesting a genetic liability effect. Both diseasespecific and genetic liability effects were found for the face processing network, which included the amygdala. Patients exhibited lower coordinated network activity compared to controls and relatives across all facial discrimination conditions. Additionally, in relation to the other emotion discrimination conditions, a heightened coordinated response during fear and anger discrimination was observed in schizophrenia compared to other conditions, whereas relatives demonstrated heightened coordinated activity for anger discrimination only relative to other emotion conditions. With regards to brain functioning, this study found that schizophrenia is associated with abnormal processing of threat-related information, and that in part may be associated with the genetic risk for the disorder, suggesting that the facial and emotion processing network could be targeted for intervention. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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