Abnormal Brain Activation During Theory of Mind Tasks in Schizophrenia: A Meta-Analysis.
Social cognition abilities are severely impaired in schizophrenia (SZ). The current meta-analysis used foci of 21 individual studies on functional abnormalities in the schizophrenic brain in order to identify regions that reveal convergent under- or over-activation during theory of mind (TOM) tasks....
| Publicado en: | Schizophrenia Bulletin Vol. 43; no. 6; pp. 1240 - 1251 |
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| Autores principales: | , , , , |
| Formato: | pictorial research systematic review tables/charts Journal Article |
| Publicado: |
Oxford University Press / USA
Nov2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=125851447&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 125851447 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 05867614 2CZ jtl: Schizophrenia Bulletin issn: 05867614 maglogo: N pubinfo: dt: Nov2017 vid: 43 iid: 6 pid: 622 pub: Oxford University Press / USA artinfo: ui: 125851447 125851447 125851447 10.1093/schbul/sbx073 125851447 ppf: 1240 ppct: 11 formats: tig: atl: Abnormal Brain Activation During Theory of Mind Tasks in Schizophrenia: A Meta-Analysis. aug: au: Kronbichler, Lisa Tschernegg, Melanie Martin, Anna Isabel Schurz, Matthias Kronbichler, Martin affil: Neuroscience Institute, Paracelsus Medical University, Christian-Doppler Clinic, Salzburg, Austria sug: subj: Theory of Mind Evaluation Brain Physiopathology Schizophrenia Human Systematic Review Meta Analysis Quantitative Studies Data Analysis Software Temporal Lobe Physiopathology Parietal Lobe Physiopathology DSM ab: Social cognition abilities are severely impaired in schizophrenia (SZ). The current meta-analysis used foci of 21 individual studies on functional abnormalities in the schizophrenic brain in order to identify regions that reveal convergent under- or over-activation during theory of mind (TOM) tasks. Studies were included in the analyses when contrasting tasks that require the processing of mental states with tasks which did not. Only studies that investigated patients with an ICD or DSM diagnosis were included. Quantitative voxel-based meta-analyses were done using Seed-based d Mapping software. Common TOM regions like medial-prefrontal cortex and temporo-parietal junction revealed abnormal activation in schizophrenic patients: Under-activation was identified in the medial prefrontal cortex, left orbito-frontal cortex, and in a small section of the left posterior temporo-parietal junction. Remarkably, robust over-activation was identified in a more dorsal, bilateral section of the temporo-parietal junction. Further abnormal activation was identified in medial occipito-parietal cortex, right premotor areas, left cingulate gyrus, and lingual gyrus. The findings of this study suggest that SZ patients simultaneously show over- and under-activation in TOM-related regions. Especially interesting, temporo- parietal junction reveals diverging activation patterns with an under-activating left posterior and an over-activating bilateral dorsal section. In conclusion, SZ patients show less specialized brain activation in regions linked to TOM and increased activation in attention-related networks suggesting compensatory effects. pubtype: Academic Journal doctype: meta analysis pictorial research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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