Addition of T2-guided optical tomography improves noncontrast breast magnetic resonance imaging diagnosis.
Background: While dynamic contrast-enhanced magnetic resonance imaging (DCE MRI) is recognized as the most sensitive examination for breast cancer detection, it has a substantial false positive rate and gadolinium (Gd) contrast agents are not universally well tolerated. As a result, alternatives to...
| Publicado en: | Breast Cancer Research Vol. 19; pp. 1 - 10 |
|---|---|
| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
BioMed Central
10/24/2017
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=125909767&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 125909767 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14655411 8UYJ jtl: Breast Cancer Research issn: 14655411 maglogo: N pubinfo: dt: 10/24/2017 vid: 19 pid: 24147 pub: BioMed Central artinfo: ui: 125909767 125909767 NLM29065920 125909767 10.1186/s13058-017-0902-x NLM29065920 125909767 ppf: 1 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Addition of T2-guided optical tomography improves noncontrast breast magnetic resonance imaging diagnosis. aug: au: Jinchao Feng Junqing Xu Shudong Jiang Hong Yin Yan Zhao Jiang Gui Ke Wang Xiuhua Lv Fang Ren Pogue, Brian W. Paulsen, Keith D. Feng, Jinchao Xu, Junqing Jiang, Shudong Yin, Hong Zhao, Yan Gui, Jiang Wang, Ke Lv, Xiuhua Ren, Fang affil: Thayer School of Engineering, Dartmouth College, 14 Engineering Drive, Hanover, NH 03755, USA sug: subj: Tomography, Optical Methods Magnetic Resonance Imaging Methods Breast Neoplasms Diagnosis Breast Contrast Media Therapeutic Use Breast Neoplasms Female Breast Pathology Adult Image Processing, Computer Assisted Middle Age Breast Neoplasms Pathology Funding Source Human Adult: 19-44 years Middle Aged: 45-64 years Female ab: Background: While dynamic contrast-enhanced magnetic resonance imaging (DCE MRI) is recognized as the most sensitive examination for breast cancer detection, it has a substantial false positive rate and gadolinium (Gd) contrast agents are not universally well tolerated. As a result, alternatives to diagnosing breast cancer based on endogenous contrast are of growing interest. In this study, endogenous near-infrared spectral tomography (NIRST) guided by T2 MRI was evaluated to explore whether the combined imaging modality, which does not require contrast injection or involve ionizing radiation, can achieve acceptable diagnostic performance.Methods: Twenty-four subjects-16 with pathologically confirmed malignancy and 8 with benign abnormalities-were simultaneously imaged with MRI and NIRST prior to definitive pathological diagnosis. MRIs were evaluated independently by three breast radiologists blinded to the pathological results. Optical image reconstructions were constrained by grayscale values in the T2 MRI. MRI and NIRST images were used, alone and in combination, to estimate the diagnostic performance of the data. Outcomes were compared to DCE results.Results: Sensitivity, specificity, accuracy, and area under the curve (AUC) of noncontrast MRI when combined with T2-guided NIRST were 94%, 100%, 96%, and 0.95, respectively, whereas these values were 94%, 63%, 88%, and 0.81 for DCE MRI alone, and 88%, 88%, 88%, and 0.94 when DCE-guided NIRST was added.Conclusion: In this study, the overall accuracy of imaging diagnosis improved to 96% when T2-guided NIRST was added to noncontrast MRI alone, relative to 88% for DCE MRI, suggesting that similar or better diagnostic accuracy can be achieved without requiring a contrast agent. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|