Quantification of Tumor Hypoxic Fractions Using Positron Emission Tomography with [18F]Fluoromisonidazole ([18F]FMISO) Kinetic Analysis and Invasive Oxygen Measurements.
Purpose: The purpose of this study is to use dynamic [18F]fluoromisonidazole ([18F]FMISO) positron emission tomography (PET) to compare estimates of tumor hypoxic fractions (HFs) derived by tracer kinetic modeling, tissue-to-blood ratios (TBR), and independent oxygen (pO2) measurements.Procedures: B...
| Publicado en: | Molecular Imaging & Biology Vol. 19; no. 6; pp. 893 - 903 |
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| Autores principales: | , , , , , , , , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Dec2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=125951070&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 125951070 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15361632 KJU jtl: Molecular Imaging & Biology issn: 15361632 maglogo: N pubinfo: dt: Dec2017 vid: 19 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 125951070 125951070 143998596 NLM28409339 125951070 10.1007/s11307-017-1083-9 NLM28409339 125951070 ppf: 893 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Quantification of Tumor Hypoxic Fractions Using Positron Emission Tomography with [18F]Fluoromisonidazole ([18F]FMISO) Kinetic Analysis and Invasive Oxygen Measurements. aug: au: Kelada, Olivia Rockwell, Sara Zheng, Ming-Qiang Huang, Yiyun Liu, Yanfeng Booth, Carmen Decker, Roy Oelfke, Uwe Carson, Richard Carlson, David Kelada, Olivia J Booth, Carmen J Decker, Roy H Carson, Richard E Carlson, David J affil: Department of Diagnostic Radiology , Yale University School of Medicine , New Haven USA sug: subj: Neoplasms Pathology Tomography, Emission-Computed Imidazoles Analogs and Derivatives Oxygen Metabolism Neoplasms Cell Physiology Neoplasms Blood Kinetics Cell Line, Tumor Body Weights and Measures Tomography, X-Ray Computed Animal Studies Neoplasms Metabolism Muscles Metabolism Mice Imidazoles Funding Source ab: Purpose: The purpose of this study is to use dynamic [18F]fluoromisonidazole ([18F]FMISO) positron emission tomography (PET) to compare estimates of tumor hypoxic fractions (HFs) derived by tracer kinetic modeling, tissue-to-blood ratios (TBR), and independent oxygen (pO2) measurements.Procedures: BALB/c mice with EMT6 subcutaneous tumors were selected for PET imaging and invasive pO2 measurements. Data from 120-min dynamic [18F]FMISO scans were fit to two-compartment irreversible three rate constant (K 1, k 2, k 3) and Patlak models (K i). Tumor HFs were calculated and compared using K i, k 3, TBR, and pO2 values. The clinical impact of each method was evaluated on [18F]FMISO scans for three non-small cell lung cancer (NSCLC) radiotherapy patients.Results: HFs defined by TBR (≥1.2, ≥1.3, and ≥1.4) ranged from 2 to 85 % of absolute tumor volume. HFs defined by K i (>0.004 ml min cm-3) and k 3 (>0.008 min-1) varied from 9 to 85 %. HF quantification was highly dependent on metric (TBR, k 3, or K i) and threshold. HFs quantified on human [18F]FMISO scans varied from 38 to 67, 0 to 14, and 0.1 to 27 %, for each patient, respectively, using TBR, k 3, and K i metrics.Conclusions: [18F]FMISO PET imaging metric choice and threshold impacts hypoxia quantification reliability. Our results suggest that tracer kinetic modeling has the potential to improve hypoxia quantification clinically as it may provide a stronger correlation with direct pO2 measurements. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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