MiR-375 and YAP1 expression profiling in medullary thyroid carcinoma and their correlation with clinical-pathological features and outcome.
Medullary thyroid cancer (MTC) is a tumor marked by an indolent growth for which few prognostic factors and therapeutic strategies are actually available. Different studies have recently appraised well-differentiated thyroid cancers are characterized by a dysregulation in different microRNA sets; ho...
| Publicado en: | Virchows Archiv: European Journal of Pathology Vol. 471; no. 5; pp. 651 - 659 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Nov2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=126017140&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 126017140 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09456317 O1Z jtl: Virchows Archiv: European Journal of Pathology issn: 09456317 maglogo: N pubinfo: dt: Nov2017 vid: 471 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 126017140 126017140 144144912 NLM28861609 126017140 10.1007/s00428-017-2227-7 NLM28861609 126017140 ppf: 651 ppct: 8 formats: fmt: @attributes: type: P tig: atl: MiR-375 and YAP1 expression profiling in medullary thyroid carcinoma and their correlation with clinical-pathological features and outcome. aug: au: Galuppini, Francesca Bertazza, Loris Barollo, Susi Cavedon, Elisabetta Rugge, Massimo Guzzardo, Vincenza Sacchi, Diana Watutantrige-Fernando, Sara Vianello, Federica Mian, Caterina Pennelli, Gianmaria affil: Department of Medicine (DIMED), Surgical Pathology Unit , University of Padova , Via Gabelli 61 35121 Padova Italy sug: subj: Neuroendocrine Tumors Pathology Carrier Proteins RNA Phosphoproteins Thyroid Neoplasms Pathology Child Young Adult Carrier Proteins Analysis Adolescence RNA Analysis Gene Expression Profiling Aged Male Adult Female Child, Preschool Aged, 80 and Over Phosphoproteins Analysis Middle Age Human Child: 6-12 years Adolescent: 13-18 years Aged: 65+ years Adult: 19-44 years Child, Preschool: 2-5 years Aged, 80 & over Middle Aged: 45-64 years Male Female ab: Medullary thyroid cancer (MTC) is a tumor marked by an indolent growth for which few prognostic factors and therapeutic strategies are actually available. Different studies have recently appraised well-differentiated thyroid cancers are characterized by a dysregulation in different microRNA sets; however, only few of them investigated the role of miRNA expression in MTCs. In this study, we have assessed the miR-375 expression in a series of 130 MTCs (104 are sporadic and 26 familial) with a median follow-up of 39 months (range 1-138) and then we have correlated our results with the clinical-pathological features and the patients' outcome.Moreover, we have appraised YAP1 (Yes-associated protein 1) immunohistochemical expression in the same MTC series and in 5 C-cells hyperplasia (CCH) samples as well. We observed a significant upregulation of miR-375 in all MTCs, when compared to the normal thyroid tissues. Besides, miR-375 expression was found to be closely linked to neoplastic size, a chance of thyroid capsule infiltration, the risk of lymph node metastasis, and the staging of the tumor. At the end of follow-up, only 10% (13/130) showed a tumor progression and a higher miR-375 expression was found to be closely linked to a worst patient' outcome. On the contrary, YAP1 immunohistochemical expression was sharply downregulated in tumors, whereas it was weakly expressed in CCHs. Our results suggest miR-375 plays a central role in MTC progression and, therefore, we seek following the idea that miR-375 pathway may be an effective target in novel MTC therapeutic strategies. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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