Association between obesity and risk of chronic kidney disease: A nationwide Cohort study in Taiwan.
Background and Aims: Increased body fat relates to enhanced inflammatory cytokine production, which, in turn, activates the renin-angiotensin-aldosterone system and increases the risk of chronic kidney disease (CKD). Herein, we aimed to examine the association between obesity and the risk of CKD in...
| Publicado en: | Nutrition, Metabolism & Cardiovascular Diseases Vol. 27; no. 11; pp. 1008 - 1015 |
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| Autores principales: | , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Elsevier B.V.
Nov2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=126040877&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 126040877 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09394753 1F3L jtl: Nutrition, Metabolism & Cardiovascular Diseases issn: 09394753 maglogo: N pubinfo: dt: Nov2017 vid: 27 iid: 11 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 126040877 126040877 NLM28986076 126040877 10.1016/j.numecd.2017.08.006 NLM28986076 126040877 ppf: 1008 ppct: 7 formats: tig: atl: Association between obesity and risk of chronic kidney disease: A nationwide Cohort study in Taiwan. aug: au: Lai, Y.-J. Hu, H.-Y. Lee, Y.-L. Ku, P.-W. Yen, Y.-F. Chu, D. affil: School of Medicine, National Yang-Ming University, Taipei, Taiwan sug: subj: Obesity Epidemiology Renal Insufficiency, Chronic Epidemiology Female Retrospective Design Surveys Risk Factors Time Factors Incidence Adult Taiwan Male Obesity Diagnosis Risk Assessment Body Mass Index Cross Sectional Studies Renal Insufficiency, Chronic Diagnosis Kaplan-Meier Estimator Linear Regression Multivariate Analysis Cox Proportional Hazards Model Human Adult: 19-44 years Female Male ab: Background and Aims: Increased body fat relates to enhanced inflammatory cytokine production, which, in turn, activates the renin-angiotensin-aldosterone system and increases the risk of chronic kidney disease (CKD). Herein, we aimed to examine the association between obesity and the risk of CKD in a population-representative cohort in Taiwan.Methods and Results: A multistage systematic sampling process was applied in the National Health Interview Survey (NHIS) 2000, 2005, and 2009. Participants were interviewed by a standardized face-to-face questionnaire to obtain information on their demographics, socioeconomic status, lifestyle factors, and body mass index (BMI). The BMI values were classified as follows: underweight (<18.5 kg/m2), normal (18.5-23.9 kg/m2), overweight (24-26.9 kg/m2), and obesity (≥27 kg/m2). The NHIS dataset was linked to National Health Insurance claims data to identify the incidence of CKD. Univariate and multivariate Cox proportional hazard models with competing risks were used to investigate the association between BMI and CKD incidence. We analyzed 45,012 subjects (mean age, 42.03 years; 50.09% males). During 374,254 person-years of follow-up, a total of 1913 new-onset CKD cases were identified. Kaplan-Meier curves comparing the four BMI groups revealed a significant difference (p < 0.01, log-rank test). After controlling for confounding factors, the relative risk of incident CKD was significantly higher in the obese group compared to the normal-weight group (adjusted hazard ratio = 1.32; 95% confidence interval: 1.17-1.49), with a significant linear trend (p < 0.01).Conclusion: Obesity was suggested as an independent risk factor for CKD. Further studies focusing on the effect of losing weight on CKD prevention are warranted. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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