Magnetic resonance imaging patterns of tumor regression in breast cancer patients after neo-adjuvant chemotherapy, and an analysis of the influencing factors.
The objective of this study was to analyze the patterns of breast tumor shrinkage in patients after neo-adjuvant chemotherapy ( NAC) based on magnetic resonance imaging ( MRI), and to evaluate the influential factors. Preoperative breast dynamic contrast-enhanced MRI was performed on 88 patients bef...
| Publicado en: | Breast Journal Vol. 23; no. 6; pp. 656 - 663 |
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| Autores principales: | , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Nov2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=126090109&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 126090109 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1075122X ET6 jtl: Breast Journal issn: 1075122X maglogo: Y pubinfo: dt: Nov2017 vid: 23 iid: 6 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 126090109 126090109 126090109 10.1111/tbj.12811 126090109 ppf: 656 ppct: 7 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Magnetic resonance imaging patterns of tumor regression in breast cancer patients after neo-adjuvant chemotherapy, and an analysis of the influencing factors. aug: au: Li, ManMan Xu, Bin Shao, Yingbo Liu, Hui Du, BingJie Yuan, JunHui affil: The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou China sug: subj: Breast Neoplasms Drug Therapy Chemotherapy, Adjuvant Utilization Disease Remission Diagnosis Magnetic Resonance Imaging Methods Disease Remission Classification Human Female Descriptive Statistics Multiple Regression Chi Square Test HER-2-neu Oncogene Oncogenes P-Value Female ab: The objective of this study was to analyze the patterns of breast tumor shrinkage in patients after neo-adjuvant chemotherapy ( NAC) based on magnetic resonance imaging ( MRI), and to evaluate the influential factors. Preoperative breast dynamic contrast-enhanced MRI was performed on 88 patients before NAC, every 2 weeks during their chemotherapy treatment, and the week before their surgery. The MRI enhancement pattern of the primary tumors was classified into one of four categories based on BI- RADS- MRI: type I (postcontrast mass image), II (multiple small masses image), III (postcontrast mass image with peripheral non-mass enhancement image), and IV (nonmass enhancement image). Multivariate regression and χ2 test analyses were employed to establish significant associations. Two kinds of tumor regression patterns were observed: concentric shrinkage was observed in 39 lesions of 88 patients (44.3%), and nests or dendritic shrinkage was observed for the other 49 lesions (55.7%). ER+/ HER2−, HER2+, and type I lesions were observed in 23 (62.2%), 21 (63.6%), and 29 (60.0%) patients, respectively, out of 49 nest or dendritic shrinkage pattern lesions. Triple negative breast cancer lesions, and type II, III, and IV lesions were observed in 13 (72.2%), 9 (81.8%), 10 (62.5%), and 10 (76.9%) patients, respectively, out of 39 lesions with a concentric shrinkage pattern. Molecular subtypes (χ2=7.171, P<.05) and the MRI schedule of enhancement (χ2=11.244, P<.05) were significantly associated with the tumor regression patterns. Multivariate analysis showed molecular subtypes ( P<.05) and MRI pattern enhancement ( P<.05) were significant predictive factors. Molecular subtypes and the MRI enhancement patterns of the primary tumors were significant predictive factors for tumor regression patterns of breast cancer after NAC. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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