Multiparametric voxel-based analyses of standardized uptake values and apparent diffusion coefficients of soft-tissue tumours with a positron emission tomography/magnetic resonance system: Preliminary results.
Objectives: To investigate the usefulness of voxel-based analysis of standardized uptake values (SUVs) and apparent diffusion coefficients (ADCs) for evaluating soft-tissue tumour malignancy with a PET/MR system.Methods: Thirty-five subjects with either ten low/intermediate-grade tumours or 25 high-...
| Publicado en: | European Radiology Vol. 27; no. 12; pp. 5024 - 5034 |
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| Autores principales: | , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Dec2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=126091249&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 126091249 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Dec2017 vid: 27 iid: 12 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 126091249 126091249 144113690 NLM28639049 126091249 10.1007/s00330-017-4912-y NLM28639049 126091249 ppf: 5024 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Multiparametric voxel-based analyses of standardized uptake values and apparent diffusion coefficients of soft-tissue tumours with a positron emission tomography/magnetic resonance system: Preliminary results. aug: au: Sagiyama, Koji Watanabe, Yuji Kamei, Ryotaro Hong, Sungtak Kawanami, Satoshi Matsumoto, Yoshihiro Honda, Hiroshi affil: Department of Clinical Radiology, Graduate School of Medical Sciences , Kyushu University , Higashi-ku Fukuoka Japan sug: subj: Soft Tissue Neoplasms Pathology Sarcoma Pathology Human Middle Age Diagnostic Imaging Methods Aged Pilot Studies Female Sensitivity and Specificity Adult Magnetic Resonance Imaging Methods Neoplasm Grading Methods Body Weights and Measures Prospective Studies Radiopharmaceuticals Male ROC Curve Fludeoxyglucose F 18 Validation Studies Comparative Studies Evaluation Research Multicenter Studies Middle Aged: 45-64 years Aged: 65+ years Adult: 19-44 years Female Male ab: Objectives: To investigate the usefulness of voxel-based analysis of standardized uptake values (SUVs) and apparent diffusion coefficients (ADCs) for evaluating soft-tissue tumour malignancy with a PET/MR system.Methods: Thirty-five subjects with either ten low/intermediate-grade tumours or 25 high-grade tumours were prospectively enrolled. Zoomed diffusion-weighted and fluorodeoxyglucose (18FDG)-PET images were acquired along with fat-suppressed T2-weighted images (FST2WIs). Regions of interest (ROIs) were drawn on FST2WIs including the tumour in all slices. ROIs were pasted onto PET and ADC-maps to measure SUVs and ADCs within tumour ROIs. Tumour volume, SUVmax, ADCminimum, the heterogeneity and the correlation coefficients of SUV and ADC were recorded. The parameters of high- and low/intermediate-grade groups were compared, and receiver operating characteristic (ROC) analysis was also performed.Results: The mean correlation coefficient for SUV and ADC in high-grade sarcomas was lower than that of low/intermediate-grade tumours (-0.41 ± 0.25 vs. -0.08 ± 0.34, P < 0.01). Other parameters did not differ significantly. ROC analysis demonstrated that correlation coefficient showed the best diagnostic performance for differentiating the two groups (AUC 0.79, sensitivity 96.0%, specificity 60%, accuracy 85.7%).Conclusions: SUV and ADC determined via PET/MR may be useful for differentiating between high-grade and low/intermediate-grade soft tissue tumours.Key Points: • PET/MR allows voxel-based comparison of SUVs and ADCs in soft-tissue tumours. • A comprehensive assessment of internal heterogeneity was performed with scatter plots. • SUVmax or ADCminimum could not differentiate high-grade sarcoma from low/intermediate-grade tumours. • Only the correlation coefficient between SUV and ADC differentiated the two groups. • The correlation coefficient showed the best diagnostic performance by ROC analysis. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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