Clinical, Epidemiological, and Histopathological Features of Respiratory Involvement in Rheumatoid Arthritis.

Although by definition rheumatoid arthritis (RA) is an articular disorder, it is a systemic disease, and 18–40% of patients experience extra-articular manifestations (EAMs). The involvement of the respiratory system occurs in about 30–40% of RA patients, and in about 10–20% of them it represents the...

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Publicado en:BioMed Research International Vol. 2017; pp. 1 - 9
Autores principales: Alunno, Alessia, Gerli, Roberto, Giacomelli, Roberto, Carubbi, Francesco
Formato: review tables/charts Journal Article
Publicado: Wiley-Blackwell 11/7/2017
Acceso en línea:Ver este registro en EBSCOhost
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      dt: 11/7/2017
      vid: 2017
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      pub: Wiley-Blackwell
      place: Malden, Massachusetts
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        126092237
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        10.1155/2017/7915340
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        atl: Clinical, Epidemiological, and Histopathological Features of Respiratory Involvement in Rheumatoid Arthritis.
      aug:
        au:
          Alunno, Alessia
          Gerli, Roberto
          Giacomelli, Roberto
          Carubbi, Francesco
        affil: Rheumatology Unit, Department of Medicine, University of Perugia, Perugia, Italy
      sug:
        subj:
          Arthritis, Rheumatoid Complications
          Arthritis, Rheumatoid Pathology
          Respiratory Tract Diseases Risk Factors
          Prognosis
          Respiratory Tract Diseases Symptoms
      ab: Although by definition rheumatoid arthritis (RA) is an articular disorder, it is a systemic disease, and 18–40% of patients experience extra-articular manifestations (EAMs). The involvement of the respiratory system occurs in about 30–40% of RA patients, and in about 10–20% of them it represents the first manifestation of RA. A wide range of pulmonary manifestations are detectable in RA patients, including pulmonary parenchymal disease, pleural involvement, and airway and pulmonary inflammation. The clinical, radiological, and histological spectra of respiratory manifestations in RA reflect chronic immune activation, increased susceptibility to infection (often related to immunosuppressive medications), or direct drug. The type and severity of pulmonary involvement influence the prognosis, ranging from mild self-limiting conditions to severe life-threatening complications. Herein, we reviewed the various manifestations of respiratory involvement in RA, providing an overview on epidemiological, histological, clinical, and radiological data.
      pubtype: Academic Journal
      doctype:
        review
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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