Assessment of Drug-Drug Interaction in Ayder Comprehensive Specialized Hospital, Mekelle, Northern Ethiopia: A Retrospective Study.
Introduction. Adverse drug interaction is a major cause of morbidity and mortality. Its occurrence is influenced by a multitude of factors. The influences of drug-drug interactions (DDIs) can be minimized through creation of awareness to health care professionals. Objective. The objective of this st...
| Publicado en: | BioMed Research International Vol. 2017; pp. 1 - 7 |
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| Autores principales: | , , , , , |
| Formato: | equations & formulas research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
11/8/2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=126115104&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 126115104 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 11/8/2017 vid: 2017 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 126115104 126115104 126115104 10.1155/2017/9792363 126115104 ppf: 1 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Assessment of Drug-Drug Interaction in Ayder Comprehensive Specialized Hospital, Mekelle, Northern Ethiopia: A Retrospective Study. aug: au: Gebretsadik, Zeru Gebrehans, Micheale Getnet, Desalegn Gebrie, Desye Alema, Tsgab Belay, Yared Belete affil: Mekelle University, School of Pharmacy, Pharmacoepidemiology and Social Pharmacy Courses and Research Team, Mekelle, Ethiopia sug: subj: Drug Interactions Medical Organizations Hospitals, Special Human Ethiopia Geographic Locations Retrospective Design Adverse Drug Event Prevention and Control Adverse Drug Event Risk Factors Patient Care Prescriptions, Drug Evaluation Age Factors Polypharmacy Adverse Effects Data Analysis Software Bivariate Statistics Odds Ratio Prescribing Patterns Male Female Adult Middle Age Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Introduction. Adverse drug interaction is a major cause of morbidity and mortality. Its occurrence is influenced by a multitude of factors. The influences of drug-drug interactions (DDIs) can be minimized through creation of awareness to health care professionals. Objective. The objective of this study was to assess DDIs in Ayder Comprehensive Specialized Hospital (ACSH). Methodology. A retrospective study design was employed on patient prescriptions available in the outpatient department of pharmacy and filled from September 2016 to February 2017 in ACSH. Result. From the 600 prescription records assessed, the average number of drugs on single prescription was 2.73. Regarding the interaction observed 34 (9.63%) prescriptions with major drug-drug interaction, 210 (59.5%) moderate, 87 (24.65%) minor, and 22 (6.22%) unknown were identified. Age category showed significant association to affect the occurrence of DDIs and polypharmacy had statistically significant association with DDIs in bivariate analysis which was lost in adjusted OR. Conclusion. From the current study it can be concluded that nearly half of the prescription ordered in ACSH contained DDIs and from the prescription with interacting medications majority of them had moderate DDIs. pubtype: Academic Journal doctype: equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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