Effect of low-intensity whole-body vibration on bone defect repair and associated vascularization in mice.
Low-intensity whole-body vibration (LIWBV) may stimulate bone healing, but the involvement of vascular ingrowth, which is essential for bone regeneration, has not been well examined. We thus investigated the LIWBV effect on vascularization during early-stage bone healing. Mice aged 13 weeks were sub...
| Publicado en: | Medical & Biological Engineering & Computing Vol. 55; no. 12; pp. 2257 - 2267 |
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| Autores principales: | , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Dec2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=126132862&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 126132862 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01400118 PO0 jtl: Medical & Biological Engineering & Computing issn: 01400118 maglogo: N pubinfo: dt: Dec2017 vid: 55 iid: 12 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 126132862 126132862 144077963 NLM28660538 126132862 10.1007/s11517-017-1664-4 NLM28660538 126132862 ppf: 2257 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Effect of low-intensity whole-body vibration on bone defect repair and associated vascularization in mice. aug: au: Matsumoto, Takeshi Goto, Daichi affil: Department of Mechanical Science and Bioengineering , Osaka University Graduate School of Engineering Science , 1-3 Machikaneyama Toyonaka 560-8531 Japan sug: subj: Tibia Radiation Effects Vibration Therapeutic Use Neovascularization, Physiologic Radiation Effects Tibia Blood Supply Bone Regeneration Radiation Effects Tomography, X-Ray Computed Male Mice Tibia Injuries Tibia Animal Studies Funding Source Male ab: Low-intensity whole-body vibration (LIWBV) may stimulate bone healing, but the involvement of vascular ingrowth, which is essential for bone regeneration, has not been well examined. We thus investigated the LIWBV effect on vascularization during early-stage bone healing. Mice aged 13 weeks were subjected to cortical drilling on tibial bone. Two days after surgery (day 0), mice were exposed daily to sine-wave LIWBV at 30 Hz and 0.1 g peak-to-peak acceleration for 20 min/day (Vib) or were sham-treated (sham). Following vascular casting with a zirconium-based contrast agent on days 6, 9, or 12 and sacrifice, vascular and bone images were obtained by K-edge subtraction micro-CT using synchrotron lights. Bone regeneration advanced more in the Vib group from days 9 to 12. The vascular volume fraction decreased from days 6 to 9 in both groups; however, from days 9 to 12, it was increased in shams, while it stabilized in the Vib group. The vascular volume fraction tended to be or was smaller in the Vib group on days 6 and 12. The vessel number density was higher on day 9 but lower on day 12 in the Vib group. These results suggest that the LIWBV-promoted bone repair is associated with the modulation of vascularization, but additional studies are needed to determine the causality of this association. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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