Effects of oral Δ-tetrahydrocannabinol on the cerebral processing of olfactory input in healthy non-addicted subjects.
Background: Considering the increasing acknowledgment of the human sense of smell as a significant component of the quality of life, olfactory drug effects gain potential clinical importance. A recent observation in a human experimental context indicated that Δ-tetrahydrocannabinol (THC) impaired th...
| Publicado en: | European Journal of Clinical Pharmacology Vol. 73; no. 12; pp. 1579 - 1588 |
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| Autores principales: | , , , , , , |
| Formato: | diagnostic images research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Springer Nature
Dec2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=126198127&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 126198127 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00316970 NP9 jtl: European Journal of Clinical Pharmacology issn: 00316970 maglogo: N pubinfo: dt: Dec2017 vid: 73 iid: 12 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 126198127 126198127 143934300 126198127 10.1007/s00228-017-2331-2 126198127 ppf: 1579 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Effects of oral Δ-tetrahydrocannabinol on the cerebral processing of olfactory input in healthy non-addicted subjects. aug: au: Walter, Carmen Oertel, Bruno Felden, Lisa Nöth, Ulrike Vermehren, Johannes Deichmann, Ralf Lötsch, Jörn affil: Fraunhofer Institute of Molecular Biology and Applied Ecology - Project Group Translational Medicine and Pharmacology (IME-TMP) , Theodor - Stern - Kai 7 60590 Frankfurt am Main Germany sug: subj: Cannabis Pharmacodynamics Administration, Oral Smell Drug Effects Cerebral Cortex Physiology Human Randomized Controlled Trials Placebos Crossover Design Amygdala Hippocampus Correlational Studies Magnetic Resonance Imaging Methods Hydrogen Sulfide Aldehydes ab: Background: Considering the increasing acknowledgment of the human sense of smell as a significant component of the quality of life, olfactory drug effects gain potential clinical importance. A recent observation in a human experimental context indicated that Δ-tetrahydrocannabinol (THC) impaired the subject's performance in olfactory tests. To further analyze the role of THC in human olfaction, the present report addresses its effects on the central processing of olfactory stimuli. Methods: Employing a placebo-controlled randomized crossover design, an oral dose of 20 mg THC was administered in 15 healthy volunteers. The central processing of olfactory input, consisting of short pulses of gaseous vanillin or hydrogen sulfide, and for comparison, of non-odorous but painful carbon dioxide, were investigated before and after administration of THC or placebo in a pharmacological functional magnet resonance imaging study. Results: Following THC administration, the vanillin stimuli lost their pleasantness and became hedonically inert. This observation had its functional correlate in reduced stimulus-associated brain activations located in the left amygdala, the hippocampus and superior temporal pole (peak MNI coordinates x = − 27, y = − 1, z = − 26 mm p = 0.039). Differences in amygdala activations were significantly correlated with the corresponding differences in vanillin pleasantness ( p = 0.025). By contrast, no effects were observed on the perception of processing of HS stimuli. Conclusions: The results support that THC induced a modulation of the central processing of olfactory input. The THC-induced reduction in the pleasantness of a pleasurable odor was accompanied by reduced activations in the limbic system. Results agree with previous observation of negative effects of cannabinoids on the human sense of smell and strengthen the evidence that THC-based medications will be among drugs with olfactory side effects. pubtype: Academic Journal doctype: diagnostic images research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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