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Synaptogenesis in the Cerebellum of Offspring Born to Diabetic Mothers.

There is increasing evidence that maternal diabetes mellitus during the pregnancy is associated with a higher risk of neurodevelopmental and neurofunctional anomalies including motor dysfunctions, learning deficits, and behavioral problems in offspring. The cerebellum is a part of the brain that has...

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Published in:Journal of Pediatric Neurosciences Vol. 12; no. 3; pp. 215 - 222
Main Authors: Hami, Javad, Vafaei-Nezhad, Saeed, Sadeghi, Akram, Ghaemi, Kazem, Taheri, Mohammad-Mahdi Hasanzadeh, Fereidouni, Mohammad, Ivar, Ghasem, Hosseini, Mehran
Format: review Journal Article
Published: Wolters Kluwer India Pvt Ltd Jul-Sep2017
Online Access:View this record in EBSCOhost
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      jtl: Journal of Pediatric Neurosciences
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      dt: Jul-Sep2017
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      pub: Wolters Kluwer India Pvt Ltd
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        10.4103/jpn.JPN_144_16
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        atl: Synaptogenesis in the Cerebellum of Offspring Born to Diabetic Mothers.
      aug:
        au:
          Hami, Javad
          Vafaei-Nezhad, Saeed
          Sadeghi, Akram
          Ghaemi, Kazem
          Taheri, Mohammad-Mahdi Hasanzadeh
          Fereidouni, Mohammad
          Ivar, Ghasem
          Hosseini, Mehran
        affil: Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran
      sug:
        subj:
          Cerebellum Physiopathology
          Neural Transmission Physiology
          Diabetes Mellitus, Gestational
          Developmental Disabilities Risk Factors
          Motor Skills Disorders Risk Factors
          Learning Disorders Risk Factors
          Child Behavior Disorders Risk Factors
          Membrane Proteins Metabolism
          Cognition Disorders
          Sensation Disorders
          Attention
          Memory
      ab: There is increasing evidence that maternal diabetes mellitus during the pregnancy is associated with a higher risk of neurodevelopmental and neurofunctional anomalies including motor dysfunctions, learning deficits, and behavioral problems in offspring. The cerebellum is a part of the brain that has long been recognized as a center of movement balance and motor coordination. Moreover, recent studies in humans and animals have also implicated the cerebellum in cognitive processing, sensory discrimination, attention, and learning and memory. Synaptogenesis is one of the most crucial events during the development of the central nervous system. Synaptophysin (SYP) is an integral membrane protein of synaptic vesicles and is considered to be a marker for synaptic density and synaptogenesis. Here, we review the manuscripts focusing on the negative impacts of maternal diabetes in pregnancy on the expression or localization of SYP in the developing cerebellar cortex. We believe that the alteration in synaptogenesis or synapse density may be part of the cascade of events through which diabetes in pregnant women affects the newborn’s cerebellum.
      pubtype: Academic Journal
      doctype:
        review
        Journal Article
      ougenre: Article
    language: English
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